Augmentation of Tendon and Ligament Repair with Fiber‐Reinforced Hydrogel Composites
Abstract: This review highlights the promise of fiber‐reinforced hydrogel composites (FRHCs) for augmenting tendon and ligament repair and regeneration. Composed of reinforcing fibers embedded in a hydrogel, these scaffolds provide both mechanical strength and a conducive microenvironment for biological processes required for connective tissue regeneration. Typical properties of FRHCs are discussed, highlighting their ability to simultaneously fulfill essential mechanical and biological design criteria for a regenerative scaffold. Furthermore, features of FRHCs are described that improve specific biological aspects of tendon healing including mesenchymal progenitor cell recruitment, early polarization to a pro‐regenerative immune response, tenogenic differentiation of recruited progenitor cells, and subsequent production of a mature, aligned collagenous matrix. Finally, the review offers a perspective on clinical translation of tendon FRHCs and outlines key directions for future work.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Augmentation of Tendon and Ligament Repair with Fiber‐Reinforced Hydrogel Composites ; day:12 ; month:08 ; year:2024 ; extent:13
Advanced healthcare materials ; (12.08.2024) (gesamt 13)
- Urheber
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Kent, Robert N.
Huang, Alice H.
Baker, Brendon M.
- DOI
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10.1002/adhm.202400668
- URN
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urn:nbn:de:101:1-2408131419357.606644806775
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:47 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Kent, Robert N.
- Huang, Alice H.
- Baker, Brendon M.
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