Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments
Abstract: Periodontitis is a common disease that is difficult to treat, and if not controlled in time, it causes severe conditions, such as alveolar bone resorption and tooth loosening and loss. Periodontal ligament stem cells constitute a promising cell source for regenerative treatment of periodontitis due to their high osteogenic differentiation capacity. PDLSC osteogenesis plays a central role in periodontal regeneration through successive cytokine-mediated signaling pathways and various biochemical and physicochemical factors. However, this process is inhibited in the inflammatory periodontitis environment due to high concentrations of lipopolysaccharide. Here, we review the mechanisms that influence the osteogenic differentiation of periodontal stem cells in this inflammatory microenvironment.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments ; volume:17 ; number:1 ; year:2022 ; pages:1240-1248 ; extent:9
Open life sciences ; 17, Heft 1 (2022), 1240-1248 (gesamt 9)
- Urheber
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Jin, Shenghao
Jiang, Haitao
Sun, Yue
Li, Fang
Xia, Jianglan
Li, Yaxin
Zheng, Jiwei
Qin, Ying
- DOI
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10.1515/biol-2022-0474
- URN
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urn:nbn:de:101:1-2022091915440282976490
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:20 MESZ
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Beteiligte
- Jin, Shenghao
- Jiang, Haitao
- Sun, Yue
- Li, Fang
- Xia, Jianglan
- Li, Yaxin
- Zheng, Jiwei
- Qin, Ying
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