Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy

Abstract: Nanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography is challenging due to the size and stability constraints of conventional bubble‐based agents. Here bicones, truly tiny acoustic contrast agents based on gas vesicles (GVs), a unique class of air‐filled protein nanostructures naturally produced in buoyant microbes, are described. It is shown that these sub‐80 nm particles can be effectively detected both in vitro and in vivo, infiltrate tumors via leaky vasculature, deliver potent mechanical effects through ultrasound‐induced inertial cavitation, and are easily engineered for molecular targeting, prolonged circulation time, and payload conjugation.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy ; day:15 ; month:03 ; year:2024 ; extent:11 ; Advanced materials ; (15.03.2024) (gesamt 11)

Contributors, Places and Time

• Creator: Ling, Bill ; Gungoren, Bilge ; Yao, Yuxing ; Dutka, Przemysław ; Vassallo, Reid ; Nayak, Rohit ; Smith, Cameron A. B. ; Lee, Justin ; Swift, Margaret B. ; Shapiro, Mikhail G.

Further information

• DOI: 10.1002/adma.202307106
• URN: urn:nbn:de:101:1-2024031613072153440312
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:01 AM CEST