Acute anterior uveitis after topical interferon for conjunctival intraepithelial neoplasia (CIN)
Abstract: Objective: Ocular surface squamous neoplasia (OSSN) is the most common type of non-melanocytic ocular surface tumor. Conjunctival intraepithelial neoplasia (CIN) is a type of OSSN that be medically managed by either topical interferon alpha-2b (IFN alpha-2b), 5-fluorouracil (5-FU), or mitomycin C. While a paradoxical response to IFN alpha-2b in the HIV population has been reported, we report a case of a paradoxical response in an immunocompetent individual.Methods: A 65-year-old immunocompetent female presents to the clinic with CIN.Results: She is started on topical IFN alpha-2b, resulting in an unexpected hypopyon, increased corneal epithelial defect, and increased size of the lesion. Switching to topical 5-FU resulted in decreasing size of the CIN lesion and resolution of the epithelial defect.Conclusions: Topical IFN alpha-2b can produce a paradoxical worsening of CIN lesions in some patients. Providers should be aware of this reaction, as well as the presenting signs and ...
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Acute anterior uveitis after topical interferon for conjunctival intraepithelial neoplasia (CIN) ; volume:11 ; day:20 ; month:07 ; year:2021
GMS ophthalmology cases ; 11 (20.07.2021)
- Classification
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Medizin, Gesundheit
- Creator
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Naravane, Ameay V.
Weber, Jacquelyn
Barucha, Grishma
Hou, Joshua H.
- DOI
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10.3205/oc000184
- URN
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urn:nbn:de:0183-oc0001849
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:59 AM CEST
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Associated
- Naravane, Ameay V.
- Weber, Jacquelyn
- Barucha, Grishma
- Hou, Joshua H.
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Recurrence of Primary Acquired Melanosis and Conjunctival Intraepithelial Neoplasia
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Pathways of IFN-alpha Activation in Patients with Cervical Intraepithelial Neoplasia (CIN)
HIF-1α, HIF-2α, and ProExC: diagnostic or prognostic relevance in conjunctival intraepithelial neoplasia?
HIF-1α, HIF-2α, and ProExC: diagnostic or prognostic relevance in conjunctival intraepithelial neoplasia?
Underdiagnosis of cervical intraepithelial neoplasia (CIN) 2 or Worse Lesion in Women with a Previous Colposcopy-Guided Biopsy Showing CIN 1
microRNAs’ differential regulations mediate the progress of Human Papillomavirus (HPV)-induced Cervical Intraepithelial Neoplasia (CIN)
Dysbiotic Co-Factors in Cervical Cancer. How the Microbiome Influences the Development of Cervical Intraepithelial Neoplasia (CIN)
Regulation of LCoR and RIP140 expression in cervical intraepithelial neoplasia and correlation with CIN progression and dedifferentiation
Microarray expression analysis of prostatic intraepithelial neoplasia
Lobular intraepithelial neoplasia arising within breast fibroadenoma
Conjunctival Intraepithelial Neoplasia in a Patient Presenting with Pigmented Conjunctival Lesion
Recurrence of Primary Acquired Melanosis and Conjunctival Intraepithelial Neoplasia
Intraepithelial neoplasia
Pathways of IFN-alpha Activation in Patients with Cervical Intraepithelial Neoplasia (CIN)
HIF-1α, HIF-2α, and ProExC: diagnostic or prognostic relevance in conjunctival intraepithelial neoplasia?
HIF-1α, HIF-2α, and ProExC: diagnostic or prognostic relevance in conjunctival intraepithelial neoplasia?
Underdiagnosis of cervical intraepithelial neoplasia (CIN) 2 or Worse Lesion in Women with a Previous Colposcopy-Guided Biopsy Showing CIN 1
microRNAs’ differential regulations mediate the progress of Human Papillomavirus (HPV)-induced Cervical Intraepithelial Neoplasia (CIN)
Dysbiotic Co-Factors in Cervical Cancer. How the Microbiome Influences the Development of Cervical Intraepithelial Neoplasia (CIN)
Regulation of LCoR and RIP140 expression in cervical intraepithelial neoplasia and correlation with CIN progression and dedifferentiation
Microarray expression analysis of prostatic intraepithelial neoplasia