Acute anterior uveitis after topical interferon for conjunctival intraepithelial neoplasia (CIN)
Abstract: Objective: Ocular surface squamous neoplasia (OSSN) is the most common type of non-melanocytic ocular surface tumor. Conjunctival intraepithelial neoplasia (CIN) is a type of OSSN that be medically managed by either topical interferon alpha-2b (IFN alpha-2b), 5-fluorouracil (5-FU), or mitomycin C. While a paradoxical response to IFN alpha-2b in the HIV population has been reported, we report a case of a paradoxical response in an immunocompetent individual.Methods: A 65-year-old immunocompetent female presents to the clinic with CIN.Results: She is started on topical IFN alpha-2b, resulting in an unexpected hypopyon, increased corneal epithelial defect, and increased size of the lesion. Switching to topical 5-FU resulted in decreasing size of the CIN lesion and resolution of the epithelial defect.Conclusions: Topical IFN alpha-2b can produce a paradoxical worsening of CIN lesions in some patients. Providers should be aware of this reaction, as well as the presenting signs and ...
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Acute anterior uveitis after topical interferon for conjunctival intraepithelial neoplasia (CIN) ; volume:11 ; day:20 ; month:07 ; year:2021
GMS ophthalmology cases ; 11 (20.07.2021)
- Klassifikation
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Medizin, Gesundheit
- Urheber
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Naravane, Ameay V.
Weber, Jacquelyn
Barucha, Grishma
Hou, Joshua H.
- DOI
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10.3205/oc000184
- URN
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urn:nbn:de:0183-oc0001849
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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2025-08-14T10:59:25+0200
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Beteiligte
- Naravane, Ameay V.
- Weber, Jacquelyn
- Barucha, Grishma
- Hou, Joshua H.
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Regulation of LCoR and RIP140 expression in cervical intraepithelial neoplasia and correlation with CIN progression and dedifferentiation
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