Movement disorders in hereditary spastic paraplegias
Abstract: Background Hereditary or familial spastic paraplegias (SPG) comprise a group of genetically and phenotypically heterogeneous diseases characterized by progressive degeneration of the corticospinal tracts. The complicated forms evolve with other various neurological signs and symptoms, including movement disorders and ataxia. Objective To summarize the clinical descriptions of SPG that manifest with movement disorders or ataxias to assist the clinician in the task of diagnosing these diseases. Methods We conducted a narrative review of the literature, including case reports, case series, review articles and observational studies published in English until December 2022. Results Juvenile or early-onset parkinsonism with variable levodopa-responsiveness have been reported, mainly in SPG7 and SPG11. Dystonia can be observed in patients with SPG7, SPG11, SPG22, SPG26, SPG35, SPG48, SPG49, SPG58, SPG64 and SPG76. Tremor is not a frequent finding in patients with SPG, but it is described in different types of SPG, including SPG7, SPG9, SPG11, SPG15, and SPG76. Myoclonus is rarely described in SPG, affecting patients with SPG4, SPG7, SPG35, SPG48, and SPOAN (spastic paraplegia, optic atrophy, and neuropathy). SPG4, SPG6, SPG10, SPG27, SPG30 and SPG31 may rarely present with ataxia with cerebellar atrophy. And autosomal recessive SPG such as SPG7 and SPG11 can also present with ataxia. Conclusion Patients with SPG may present with different forms of movement disorders such as parkinsonism, dystonia, tremor, myoclonus and ataxia. The specific movement disorder in the clinical manifestation of a patient with SPG may be a clinical clue for the diagnosis.
- Alternative title
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Distúrbios de movimento em paraplegia espástica hereditária
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Movement disorders in hereditary spastic paraplegias ; volume:81 ; number:11 ; year:2023 ; pages:1000-1007
Arquivos de neuro-psiquiatria ; 81, Heft 11 (2023), 1000-1007
- Contributor
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Pedroso, Jose Luiz
Vale, Thiago Cardoso
Freitas, Julian Letícia de
Araújo, Filipe Miranda Milagres
Meira, Alex Tiburtino
Neto, Pedro Braga
França, Marcondes C.
Tumas, Vitor
Teive, Helio
Barsottini, Orlando G. P.
- DOI
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10.1055/s-0043-1777005
- URN
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urn:nbn:de:101:1-2024011810394701183056
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:21 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Pedroso, Jose Luiz
- Vale, Thiago Cardoso
- Freitas, Julian Letícia de
- Araújo, Filipe Miranda Milagres
- Meira, Alex Tiburtino
- Neto, Pedro Braga
- França, Marcondes C.
- Tumas, Vitor
- Teive, Helio
- Barsottini, Orlando G. P.
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Early-onset hereditary spastic paraplegia: case report
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Understanding disease modulators of SPG11‐linked hereditary spastic paraplegia.
Neurosurgical management of non-spastic movement disorders
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Reduced penetrance in hereditary movement disorders
Translational research approaches in hereditary spastic paraplegia
Neurometabolic Dysfunction in SPG11 Hereditary Spastic Paraplegia
Mania associated with complicated hereditary spastic paraparesis
Early-onset hereditary spastic paraplegia: case report
Parkinsonism in complex neurogenetic disorders: lessons from hereditary dementias, adult-onset ataxias and spastic paraplegias
Adaptor protein complex 5-related hereditary spastic paraplegias
Gene identification in Hereditary Spastic Paraplegias and characterization of Spastic Paraplegia type 58 (SPG58)
A Rare Patient with Hereditary Spastic Paraparesis with Parkinsonism
Understanding disease modulators of SPG11‐linked hereditary spastic paraplegia.
Neurosurgical management of non-spastic movement disorders
Movement disorders in hereditary spastic paraplegia (HSP): a systematic review and individual participant data meta-analysis
Reduced penetrance in hereditary movement disorders
Translational research approaches in hereditary spastic paraplegia
Neurometabolic Dysfunction in SPG11 Hereditary Spastic Paraplegia
Mania associated with complicated hereditary spastic paraparesis
Early-onset hereditary spastic paraplegia: case report
Parkinsonism in complex neurogenetic disorders: lessons from hereditary dementias, adult-onset ataxias and spastic paraplegias
Adaptor protein complex 5-related hereditary spastic paraplegias
Gene identification in Hereditary Spastic Paraplegias and characterization of Spastic Paraplegia type 58 (SPG58)
A Rare Patient with Hereditary Spastic Paraparesis with Parkinsonism