A New Sarcoma Shortly after Treatment for High-Grade Glioma with Adjuvant Chemoradiation: A Case Report

Abstract: Introduction: High-grade gliomas are central nervous system tumors conventionally treated with surgery followed by adjuvant chemoradiotherapy. Secondary cancer due to radiation therapy is a rare yet established phenomenon that typically occurs years after radiation therapy. Case Presentation: In this case, we discuss an early presentation of a second cancer adjacent to the radiation field. This case report is of a 52-year-old male who developed a new scalp sarcoma at the site of primary surgery 8 months after radiation therapy. Genetic testing revealed a heterozygous missense variant in the NF1 gene, a variant of uncertain significance. The report highlights that this case does not conform to the expected criteria for postradiation sarcoma in terms of timing. Conclusion: Secondary cancers may arise earlier than expected, even in phenotypically normal patients, as they may have unmanifested variants of relevant mutations. The question of pre-radiotherapy screening for radiosensitivity syndromes and diseases requires further study, as current data are limited and do not provide enough insight into the significance of different genetic variants.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: A New Sarcoma Shortly after Treatment for High-Grade Glioma with Adjuvant Chemoradiation: A Case Report ; volume:17 ; number:1 ; year:2024 ; pages:573-580 ; extent:8 ; Case reports in oncology ; 17, Heft 1 (2024), 573-580 (gesamt 8)

Contributors, Places and Time

• Creator: Madkhali, Abdossalam M. ; Alaluan, Hasah F. ; Alnajeim, Mohammed H. ; Al Saeed, Eyad F. ; Ajlan, Abdulrazag M. ; Abdelwarith, Ahmed ; Abduh, Ali ; Albanyan, Saleh ; Alqurashi, Ashwag ; Alkhalidi, Hisham

Further information

• DOI: 10.1159/000538508
• URN: urn:nbn:de:101:1-2406270107412.710880884950
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:50 AM CEST