GC-MS profile of extracts of an endophytic fungus Alternaria and evaluation of its anticancer and antibacterial potentialities
Abstract: Using microbial endophytes to produce bioactive compounds is a reliable scientific method. This investigation aimed to use the Acacia plant for isolating an endophytic fungal strain that has a bio-ability to produce a bio-crude extract. This study also encompassed the assessment of the extract’s biological efficacy as an antibacterial and anticancer agent. Samples of the Acacia plant were collected from “Shuaib Huraymila,” in Riyadh, Saudi Arabia. The isolation and identification of fungal endophytes was done, and then, the production of crude extract was performed using the isolated endophytes. The profile gas chromatography-mass spectroscopy of the extract was determined, followed by the assessment of its biological activity against drug-resistant infections and cancer cells through in vitro examination. The findings showed that the fungal endophyte was Alternaria (Alternaria sorghi), according to internal transcribed spacer sequencing and basic local alignment search tool analysis. The minimum inhibitory concentrations of the extract were 9.1 and 4.5 mg/mL for methicillin-resistant Staphylococcus aureus and drug-resistant Candida auris, respectively, and the IC50% values were 46.6 and 23.7 mg/mL for MCF-7 and A549, respectively. The findings showed that this strain had no antagonistic action against Culex pipiens. This study concluded that the fungal endophyte isolated from the Acacia plant has the bio-ability to produce antimicrobial and anticancer agents.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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GC-MS profile of extracts of an endophytic fungus Alternaria and evaluation of its anticancer and antibacterial potentialities ; volume:21 ; number:1 ; year:2023 ; extent:8
Open chemistry ; 21, Heft 1 (2023) (gesamt 8)
- Creator
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Al-Keridis, Lamya Ahmed
Al-Mekhlafi, Fahd A.
Al-Shuraym, Laila A.
Wadaan, Muhammad A.
Al-Khalifa, Mohammed S.
- DOI
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10.1515/chem-2023-0145
- URN
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urn:nbn:de:101:1-2023102714053140699395
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:50 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Al-Keridis, Lamya Ahmed
- Al-Mekhlafi, Fahd A.
- Al-Shuraym, Laila A.
- Wadaan, Muhammad A.
- Al-Khalifa, Mohammed S.
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Cross-resistance of the pathogenic fungus Alternaria alternata to fungicides with different modes of action
Bioactive potential of endophytic fungus Chaetomium globosum and GC–MS analysis of its responsible components
Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1
LC–MS/MS and GC–MS based phytochemical perspectives and antimicrobial effects of endophytic fungus Chaetomium ovatoascomatis isolated from Euphorbia milii
Biocontrol potential and growth-promoting effect of endophytic fungus Talaromyces muroii SD1-4 against potato leaf spot disease caused by Alternaria alternata
Pogostol biosynthesis by the endophytic fungus Geniculosporium
Isochromophilones from an endophytic fungus Diaporthe sp
Transcriptome analysis of a taxol-producing endophytic fungus Cladosporium cladosporioides MD2
The antifungal properties of terpenoids from the endophytic fungus Bipolaris eleusines
Cytochalasins from Xylaria sp. CFL5, an Endophytic Fungus of Cephalotaxus fortunei
The presence of a significant endophytic fungus in mycobiome of rice seed compartments
Three new amide derivatives from the fungus Alternaria brassicicola
Cross-resistance of the pathogenic fungus Alternaria alternata to fungicides with different modes of action
Bioactive potential of endophytic fungus Chaetomium globosum and GC–MS analysis of its responsible components
Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1
LC–MS/MS and GC–MS based phytochemical perspectives and antimicrobial effects of endophytic fungus Chaetomium ovatoascomatis isolated from Euphorbia milii
Biocontrol potential and growth-promoting effect of endophytic fungus Talaromyces muroii SD1-4 against potato leaf spot disease caused by Alternaria alternata
Pogostol biosynthesis by the endophytic fungus Geniculosporium
Isochromophilones from an endophytic fungus Diaporthe sp
Transcriptome analysis of a taxol-producing endophytic fungus Cladosporium cladosporioides MD2
The antifungal properties of terpenoids from the endophytic fungus Bipolaris eleusines
Cytochalasins from Xylaria sp. CFL5, an Endophytic Fungus of Cephalotaxus fortunei
The presence of a significant endophytic fungus in mycobiome of rice seed compartments
Three new amide derivatives from the fungus Alternaria brassicicola