A Vesicular Stomatitis Virus‐Inspired DNA Nanocomplex for Ovarian Cancer Therapy
Abstract: Gene therapy provides a novel method for cancer therapy. This study shows a DNA nanocomplex that is inspired from vesicular stomatitis virus (VSV) for ovarian cancer therapy. This DNA nanocomplex consists of a cationized monomethoxy poly (ethylene glycol)‐poly (d,l‐lactide) (MPEG‐PLA) nanoparticle and a plasmid encoding the matrix protein of vesicular stomatitis virus (VSVMP) that plays a critical role in the VSV‐induced apoptosis of cancer cells. The cationized MPEG‐PLA nanoparticle that is self‐assembled by MPEG‐PLA copolymer and N ‐[1‐(2,3‐dioleoyloxy) propyl]‐N,N,N‐trimethylammonium chloride (DOTAP) has low cytotoxicity and high transfection efficiency (>80%). Intraperitoneal administration of the p VSVMP nanocomplex remarkably inhibits the intraperitoneal metastasis of ovarian cancer and does not cause significant systemic toxicity. The apoptosis induction and anti‐angiogenesis are involved in the anticancer mechanism. This work demonstrates a VSV‐inspired DNA nanocomplex that has potential application for the treatment of intraperitoneal metastasis of ovarian cancer.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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A Vesicular Stomatitis Virus‐Inspired DNA Nanocomplex for Ovarian Cancer Therapy ; volume:5 ; number:3 ; year:2018 ; extent:9
Advanced science ; 5, Heft 3 (2018) (gesamt 9)
- Urheber
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Zhao, Wei
Yang, Yuping
Song, Lingling
Kang, Tianyi
Du, Ting
Wu, Yujiao
Xiong, Meimei
Luo, Li
Long, Jianlin
Men, Ke
Zhang, Lan
Chen, Xiaoxin
Huang, Meijuan
Gou, Maling
- DOI
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10.1002/advs.201700263
- URN
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urn:nbn:de:101:1-2022082106324090738737
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:35 MESZ
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Beteiligte
- Zhao, Wei
- Yang, Yuping
- Song, Lingling
- Kang, Tianyi
- Du, Ting
- Wu, Yujiao
- Xiong, Meimei
- Luo, Li
- Long, Jianlin
- Men, Ke
- Zhang, Lan
- Chen, Xiaoxin
- Huang, Meijuan
- Gou, Maling
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