Serum asprosin levels in patients with retinopathy of prematurity

Objectives: This study was aimed to investigate the diagnostic values of serum levels of asprosin and neutrophil gelatinase-associated lipocalin (NGAL) in Retinopathy of prematurity (ROP) and to assess the role of these biomarkers on the development and progression of the condition. Methods: This study was carried out from April 2020 to February 2021 in the department of ophthalmology of a tertiary hospital in Turkey. Thirty patients diagnosed with ROP and 30 healthy newborns were included the study. Serum NGAL and asprosin levels were determined via ELISA. Results: The median serum NGAL levels were found to be similar between the ROP group and the control group (p=0.595). Median asprosin levels were significantly higher in patients diagnosed with ROP [46.58 (12.70–142.28) ng/mL] compared to healthy subjects [13.05 (10.92–17.73) ng/mL] (p=0.001). The optimal cut-off value of asprosin by ROC analysis was 30 ng/mL (AUC: 0.754, p=0.001) for diagnosing ROP. Serum asprosin levels were positively correlated with serum ALP levels and inversely correlated with gestational week, uric acid and AST values (all, p<0.005). Conclusions: Our results demonstrated that asprosin, but not NGAL, could be a biomarker for the diagnosis of ROP.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Serum asprosin levels in patients with retinopathy of prematurity ; volume:47 ; number:6 ; year:2022 ; pages:749-755 ; extent:07 ; Turkish journal of biochemistry ; 47, Heft 6 (2022), 749-755 (gesamt 07)

Contributors, Places and Time

• Creator: Yardim, Meltem ; Celik, Fatih ; Oruc, Yavuz ; Kayalp, Damla ; Beyazyildiz, Ozlem ; Yesilirmak, Didem Cemile ; Ulas, Mustafa ; Aydin, Suleyman

Further information

• DOI: 10.1515/tjb-2022-0019
• URN: urn:nbn:de:101:1-2022122713053531631915
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:21 AM CEST