Advances in CAR‐Engineered Immune Cell Generation: Engineering Approaches and Sourcing Strategies
Abstract: Chimeric antigen receptor T‐cell (CAR‐T) therapy has emerged as a highly efficacious treatment modality for refractory and relapsed hematopoietic malignancies in recent years. Furthermore, CAR technologies for cancer immunotherapy have expanded from CAR‐T to CAR‐natural killer cell (CAR‐NK), CAR‐cytokine‐induced killer cell (CAR‐CIK), and CAR‐macrophage (CAR‐MΦ) therapy. Nevertheless, the high cost and complex manufacturing processes of ex vivo generation of autologous CAR products have hampered broader application. There is an urgent need to develop an efficient and economical paradigm shift for exploring new sourcing strategies and engineering approaches toward generating CAR‐engineered immune cells to benefit cancer patients. Currently, researchers are actively investigating various strategies to optimize the preparation and sourcing of these potent immunotherapeutic agents. In this work, the latest research progress is summarized. Perspectives on the future of CAR‐engineered immune cell manufacturing are provided, and the engineering approaches, and diverse sources used for their development are focused upon.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Advances in CAR‐Engineered Immune Cell Generation: Engineering Approaches and Sourcing Strategies ; day:31 ; month:10 ; year:2023 ; extent:26
Advanced science ; (31.10.2023) (gesamt 26)
- Creator
-
Chen, Zhaozhao
Hu, Yu
Mei, Heng
- DOI
-
10.1002/advs.202303215
- URN
-
urn:nbn:de:101:1-2023110114044409800745
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:49 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Chen, Zhaozhao
- Hu, Yu
- Mei, Heng
Other Objects (12)
Acute Total Occlusion of the Abdominal Aorta in an Elderly Patient with Atrial Fibrillation
How do Confucian schools and Anglo schools differ? A latent profile analysis based on PISA 2015
Marketing research in China during the 40-year reform and opening
Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis
Hemophagocytic lymphohistiocytosis after COVID-19 vaccination
Venous Thromboembolism in COVID-19
Venous Thromboembolism in Kidney Diseases and Genetic Predisposition
Evaluation of two health education interventions to improve the varicella vaccination: a randomized controlled trial from a province in the east China
Venous Thromboembolic Diseases: Diagnosis, Management and Thrombophilia Testing: Observations on NICE Guideline [NG158]
HORIZONTAL POSITION OPTIMAL SOLUTION DETERMINATION FOR THE SATELLITE LASER RANGING SLOPE MODEL
Consolidative allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: who? When? Why?
Thrombocytopenia and thrombosis in hospitalized patients with COVID-19
Acute Total Occlusion of the Abdominal Aorta in an Elderly Patient with Atrial Fibrillation
How do Confucian schools and Anglo schools differ? A latent profile analysis based on PISA 2015
Marketing research in China during the 40-year reform and opening
Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis
Hemophagocytic lymphohistiocytosis after COVID-19 vaccination
Venous Thromboembolism in COVID-19
Venous Thromboembolism in Kidney Diseases and Genetic Predisposition
Evaluation of two health education interventions to improve the varicella vaccination: a randomized controlled trial from a province in the east China
Venous Thromboembolic Diseases: Diagnosis, Management and Thrombophilia Testing: Observations on NICE Guideline [NG158]
HORIZONTAL POSITION OPTIMAL SOLUTION DETERMINATION FOR THE SATELLITE LASER RANGING SLOPE MODEL
Consolidative allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: who? When? Why?
Thrombocytopenia and thrombosis in hospitalized patients with COVID-19
Acute Total Occlusion of the Abdominal Aorta in an Elderly Patient with Atrial Fibrillation
How do Confucian schools and Anglo schools differ? A latent profile analysis based on PISA 2015
Marketing research in China during the 40-year reform and opening
Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis
Hemophagocytic lymphohistiocytosis after COVID-19 vaccination
Venous Thromboembolism in COVID-19
Venous Thromboembolism in Kidney Diseases and Genetic Predisposition
Evaluation of two health education interventions to improve the varicella vaccination: a randomized controlled trial from a province in the east China
Venous Thromboembolic Diseases: Diagnosis, Management and Thrombophilia Testing: Observations on NICE Guideline [NG158]
HORIZONTAL POSITION OPTIMAL SOLUTION DETERMINATION FOR THE SATELLITE LASER RANGING SLOPE MODEL
Consolidative allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: who? When? Why?