Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing
The genetic material within cells plays a pivotal role in shaping the structure and function of living organisms. Manipulating an organism's genome to correct inherited abnormalities or introduce new traits holds great promise. Genetic engineering techniques offers promising pathways for precisely altering cellular genetics. Among these methodologies, clustered regularly interspaced short palindromic repeat (CRISPR), honored with the 2020 Nobel Prize in Chemistry, has garnered significant attention for its precision in editing genomes. However, the CRISPR system faces challenges when applied in vivo, including low delivery efficiency, off‐target effects, and instability. To address these challenges, innovative technologies for targeted and precise delivery of CRISPR have emerged. Engineered carrier platforms represent a substantial advancement, improving stability, precision, and reducing the side effects associated with genome editing. These platforms facilitate efficient local and systemic genome engineering of various tissues and cells, including immune cells. This review explores recent advances, benefits, and challenges of CRISPR‐based genome editing delivery. It examines various carriers including nanocarriers (polymeric, lipid‐derived, metallic, and bionanoparticles), viral particles, virus‐like particles, and exosomes, providing insights into their clinical utility and future prospects.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing ; day:25 ; month:07 ; year:2024 ; extent:33
Small science ; (25.07.2024) (gesamt 33)
- Urheber
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Rostami, Neda
Gomari, Mohammad Mahmoudi
Choupani, Edris
Abkhiz, Shadi
Fadaie, Mahmood
Eslami, Seyed Sadegh
Mahmoudi, Zahra
Zhang, Yapei
Puri, Madhu
Monfared, Fatemeh Nafe
Demireva, Elena
Uversky, Vladimir N.
Smith, Bryan Ronain
Bencherif, Sidi A.
- DOI
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10.1002/smsc.202400192
- URN
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urn:nbn:de:101:1-2407251419456.051091012445
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:01 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Rostami, Neda
- Gomari, Mohammad Mahmoudi
- Choupani, Edris
- Abkhiz, Shadi
- Fadaie, Mahmood
- Eslami, Seyed Sadegh
- Mahmoudi, Zahra
- Zhang, Yapei
- Puri, Madhu
- Monfared, Fatemeh Nafe
- Demireva, Elena
- Uversky, Vladimir N.
- Smith, Bryan Ronain
- Bencherif, Sidi A.
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