Cell‐Based Therapies for Degenerative Musculoskeletal Diseases
Abstract: Degenerative musculoskeletal diseases (DMDs), including osteoporosis, osteoarthritis, degenerative disc disease, and sarcopenia, present major challenges in the aging population. Patients with DMDs present with pain, functional decline, and reduced exercise tolerance, which result in long‐term or permanent deficits in their ability to perform daily activities. Current strategies for dealing with this cluster of diseases focus on relieving pain, but they have a limited capacity to repair function or regenerate tissue. Cell‐based therapies have attracted considerable attention in recent years owing to their unique mechanisms of action and remarkable effects on regeneration. In this review, current experimental attempts to use cell‐based therapies for DMDs are highlighted, and the modes of action of different cell types and their derivatives, such as exosomes, are generalized. In addition, the latest findings from state‐of‐the‐art clinical trials are reviewed, approaches to improve the efficiency of cell‐based therapies are summarized, and unresolved questions and potential future research directions for the translation of cell‐based therapies are identified.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Cell‐Based Therapies for Degenerative Musculoskeletal Diseases ; day:18 ; month:05 ; year:2023 ; extent:23
Advanced science ; (18.05.2023) (gesamt 23)
- Creator
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Yin, Pengbin
Jiang, Yuheng
Fang, Xuan
Wang, Daofeng
Li, Yi
Chen, Ming
Deng, Hao
Tang, Peifu
Zhang, Licheng
- DOI
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10.1002/advs.202207050
- URN
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urn:nbn:de:101:1-2023051915014248423393
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:53 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Yin, Pengbin
- Jiang, Yuheng
- Fang, Xuan
- Wang, Daofeng
- Li, Yi
- Chen, Ming
- Deng, Hao
- Tang, Peifu
- Zhang, Licheng
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