Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue

BackgroundAurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. Methods Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. Results Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. Conclusions Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue ; volume:41 ; number:01 ; year:2014 ; pages:35-39
Archives of Plastic Surgery ; 41, Heft 01 (2014), 35-39

Contributor
Cho, Moon Kyun
An, Je Min
Kim, Chul Han
Kang, Sang Gue

DOI
10.5999/aps.2014.41.1.35
URN
urn:nbn:de:101:1-2022061611040722505542
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:35 AM CEST

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Associated

  • Cho, Moon Kyun
  • An, Je Min
  • Kim, Chul Han
  • Kang, Sang Gue

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