Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489
Two divergent synthetic routes are reported offering access to four quinolone natural products from Pseudonocardia sp. CL38489. Key steps to the natural products involved a regioselective epoxidation, an intramolecular Buchwald–Hartwig amination and a final acid‐catalysed 1,3‐allylic‐alcohol rearrangement to give two of the natural products in one step. This study completes the synthesis of all eight antibacterial quinolone natural products reported in the family. In addition, this modular strategy enables an improved synthesis towards two natural products previously reported.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489 ; volume:2016 ; number:35 ; year:2016 ; pages:5799-5802 ; extent:4
European journal of organic chemistry ; 2016, Heft 35 (2016), 5799-5802 (gesamt 4)
- Urheber
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Geddis, Stephen M.
Carro, Laura
Hodgkinson, James T.
Spring, David R.
- DOI
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10.1002/ejoc.201601195
- URN
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urn:nbn:de:101:1-2022112106372520389669
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
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Beteiligte
- Geddis, Stephen M.
- Carro, Laura
- Hodgkinson, James T.
- Spring, David R.
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