Multifunctional Heterogeneous Cobalt Catalyst for the One‐Pot Synthesis of Benzimidazoles by Reductive Coupling of Dinitroarenes with Aldehydes in Water

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Abstract: The endeavor of sustainable chemistry has led to significant advancements in green methodologies aimed at minimizing environmental impact while maximizing efficiency. Herein, a straightforward synthesis of benzimidazoles by reductive coupling of o‐dinitroarenes with aldehydes is reported for the first time in aqueous media while using a non‐noble metal catalyst. This work demonstrates that the combination of nitrogen and phosphorous ligands in the synthesis of supported heteroatom‐incorporated Co nanoparticles is crucial for obtaining the desired benzimidazoles. The process achieves >99 % conversion, >99 % chemoselectivity and stability for the reduction of dinitroarenes using water as the solvent and hydrogen as the reductant under mild reaction conditions. The robustness of the catalyst has been investigated using several advanced techniques such as HRTEM, HAADF‐STEM, XEDS, EELS, and NAP‐XPS. In fact, we have shown that the introduction of N and P dopants prevents metal leaching and the sintering of the cobalt nanoparticles. Finally, to explore the general catalytic performance, a wide range of substituted dinitroarenes and benzaldehydes were evaluated, yielding benzimidazoles with competitive and scalable results, including MBIB (94 % yield), which is a compound of pharmaceutical interest.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Multifunctional Heterogeneous Cobalt Catalyst for the One‐Pot Synthesis of Benzimidazoles by Reductive Coupling of Dinitroarenes with Aldehydes in Water ; day:19 ; month:12 ; year:2024 ; extent:13
ChemSusChem ; (19.12.2024) (gesamt 13)

Creator: del Río‐Rodríguez, José Luis
Gutiérrez‐Tarriño, Silvia
Chinchilla, Lidia E.
Holgado, Juan Pedro
Villar‐García, Ignacio J.
Pérez‐Dieste, Virginia
Calvino, Jose J.
Oña‐Burgos, Pascual

DOI: 10.1002/cssc.202402141

URN: urn:nbn:de:101:1-2412191339003.062190931108

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:35 AM CEST

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del Río‐Rodríguez, José Luis
Gutiérrez‐Tarriño, Silvia
Chinchilla, Lidia E.
Holgado, Juan Pedro
Villar‐García, Ignacio J.
Pérez‐Dieste, Virginia
Calvino, Jose J.
Oña‐Burgos, Pascual

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Multifunctional Heterogeneous Cobalt Catalyst for the One‐Pot Synthesis of Benzimidazoles by Reductive Coupling of Dinitroarenes with Aldehydes in Water

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Other Objects (12)

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