Precise and Controlled Modification of Proteins using Multifunctional Chemical Constructs
Abstract: Bioconjugation of chemical entities to biologically active proteins has increased our insight in the inner workings of a cell and resulted in novel therapeutic agents. A current challenge is the efficient generation of homogeneous conjugates of native proteins, not only when isolated, but also when still present in their native environment. To do this, various features of protein‐modifying enzymes have been combined in artificial constructs. In this concept, the current status of this approach is evaluated, and the interplay between designs and protein modification will be discussed. Particular focus is directed on the protein‐binding anchor, the chemistry that is used for the modification, and the linker that connects these two units. Suggestions how to include additional elements such as a trigger‐responsive switch that regulated protein modification are also presented.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Precise and Controlled Modification of Proteins using Multifunctional Chemical Constructs ; day:04 ; month:07 ; year:2023 ; extent:6
ChemBioChem ; (04.07.2023) (gesamt 6)
- Urheber
- DOI
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10.1002/cbic.202300187
- URN
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urn:nbn:de:101:1-2023070415255068110736
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:53 MESZ
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