Immunomodulatory components of Trichinella spiralis excretory-secretory products with lactose-binding specificity

Abstract: The immunomodulatory potential of Trichinella spiralis muscle larvae excretory-secretory products (ES L1) has been well documented in vitro on dendritic cells (DCs) and in animal models of autoimmune diseases. ES L1 products possess the potential to induce tolerogenic DCs and consequently trigger regulatory mechanisms that maintain immune homeostasis. The use of ES L1 as a potential treatment for various inflammatory disorders proved to be beneficial in animal models, although the precise immunomodulatory factors have not yet been identified. This study aimed at the isolation and characterization of ES L1 components that possess galectin family member properties. Galectin-1-like proteins (TsGal-1-like) were isolated from ES L1 based on the assumption of the existence of a lactose-specific carbohydrate-recognition domain and were recognized by anti-galectin-1 antibodies in Western blot. This TsGal-1-like isolate, similar to galectin-1, induced DCs with tolerogenic properties and hen.... https://www.excli.de/index.php/excli/article/view/4954

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Immunomodulatory components of Trichinella spiralis excretory-secretory products with lactose-binding specificity ; volume:21 ; day:03 ; month:06 ; year:2022 ; EXCLI journal ; 21 (03.06.2022)

Beteiligte, Orts- und Zeitangaben

• Urheber: Ilic, Natasa ; Bojic-Trbojevic, Zanka ; Lundström-Stadelmann, Britta ; Cujic, Danica ; Mitic, Ivana ; Gruden-Movsesijan, Alisa

Weitere Informationen

• DOI: 10.17179/excli2022-4954
• URN: urn:nbn:de:101:1-2022070815003014153418
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:28 MESZ