Long-term outcome after allogeneic hematopoietic cell transplantation for myelofibrosis

Abstract: Allogeneic hematopoietic stem cell transplant remains the only curative treatment for myelofibrosis. Most post-transplantation events occur during the first two years and hence we aimed to analyze the outcome of 2-year disease-free survivors. A total of 1055 patients with myelofibrosis transplanted between 1995 and 2014 and registered in the registry of the European Society for Blood and Marrow Transplantation were included. Survival was compared to the matched general population to determine excess mortality and the risk factors that are associated. In the 2-year survivors, disease-free survival was 64% (60-68%) and overall survival was 74% (71-78%) at ten years; results were better in younger individuals and in women. Excess mortality was 14% (8-21%) in patients aged <45 years and 33% (13-53%) in patients aged ≥65 years. The main cause of death was relapse of the primary disease. Graft-versus-host disease (GvHD) before two years decreased the risk of relapse. Multivariable analysis of excess mortality showed that age, male sex recipient, secondary myelofibrosis and no GvHD disease prior to the 2-year landmark increased the risk of excess mortality. This is the largest study to date analyzing long-term outcome in patients with myelofibrosis undergoing transplant. Overall it shows a good survival in patients alive and in remission at two years. However, the occurrence of late complications, including late relapses, infectious complications and secondary malignancies, highlights the importance of screening and monitoring of long-term survivors

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Haematologica. - 104, 9 (2019) , 1782-1788, ISSN: 1592-8721

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2019
Creator
Robin, Marie
Wreede, Liesbeth Cornelia de
Wolschke, Christine
Schetelig, Johannes
Eikema, Diderik-Jan
Lint, Maria Teresa van
Knelange, Nina Simone
Beelen, Dietrich W.
Brecht, Arne Jörn
Niederwieser, Dietger
Vitek, Antonin
Bethge, Wolfgang Andreas
Arnold, Renate
Finke, Jürgen
Volin, Liisa
Yakoub-Agha, Ibrahim
Nagler, Arnon
Poiré, Xavier
Einsele, Hermann
Chevallier, Patrice
Holler, Ernst
Ljungman, Per
Robinson, Stephen
Radujkovic, Alekxandar
McLornan, Donal
Chalandon, Yves
Kröger, Nicolaus

DOI
10.3324/haematol.2018.205211
URN
urn:nbn:de:bsz:25-freidok-1507255
Rights
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Last update
25.03.2025, 1:48 PM CET

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Time of origin

  • 2019

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