Vaccination protects against acute respiratory distress syndrome (ARDS) in hospitalized patients with COVID-19

Abstract: This study aimed to analyze the effect of COVID-19 vaccination on the occurrence of ARDS in hospitalized COVID-19 patients. The study population of this retrospective, single-center cohort study consisted of hospitalized COVID-19 patients with known vaccination status and chest computed tomography imaging between July 2021 and February 2022. The impact of vaccination on ARDS in COVID-19 patients was assessed through logistic regression adjusting for demographic differences and confounding factors with statistical differences determined using confidence intervals and effect sizes. A total of 167 patients (69% male, average age 58 years, 95% CI [55; 60], 42% fully vaccinated) were included in the data analysis. Vaccinated COVID-19 patients had a reduced relative risk (RR) of developing ARDS (RR: 0.40, 95% CI [0.21; 0.62]). Consequently, non-vaccinated hospitalized patients had a 2.5-fold higher probability of developing ARDS. This risk reduction persisted after adjusting for several confounding variables (RR: 0.64, 95% CI [0.29; 0.94]) in multivariate analysis. The protective effect of COVID-19 vaccination increased with ARDS severity (RR: 0.61, 95% CI [0.37; 0.92]). Particularly, patients under 60 years old were at risk for ARDS onset and seemed to benefit from COVID-19 vaccination (RR: 0.51, 95% CI [0.20; 0.90]). COVID-19 vaccination showed to reduce the risk of ARDS occurrence in hospitalized COVID-19 patients, with a particularly strong effect in patients under 60 years old and those with more severe ARDS

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Clinical and experimental medicine. - 24, 1 (2024) , 21, ISSN: 1591-9528

Classification and Topics

• Classification: Medizin, Gesundheit

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2024
• Creator: Madrid, Julian ; Agarwal, Prerana ; Müller-Peltzer, Katharina ; Askani, Marvin ; Benning, Leo ; Selig, Mischa ; Diehl, Philipp ; Kalbhenn, Johannes ; Trummer, Georg ; Utzolino, Stefan ; Wengenmayer, Tobias ; Busch, Hans-Jörg ; Stolz, Daiana ; Rieg, Siegbert ; Panning, Marcus ; Schlett, Christopher L. ; Bamberg, Fabian ; Askani, Esther Adele

Further information

• DOI: 10.1007/s10238-023-01293-w
• URN: urn:nbn:de:bsz:25-freidok-2439183
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:55 PM CET