Effect of Cabergoline Treatment on Disease Control in Acromegaly Patients

Abstract: The aim of this study was to evaluate the efficacy of cabergoline in normalizing plasma IGF-I levels in acromegaly patients with elevated IGF-I levels after surgery and/or SRL therapy. Acromegaly patients (n: 143) were evaluated retrospectively. Patients with elevated IGF-I levels after surgery and/or SRLs therapy and a fixed dose of SRLs treatment for the last six months with no history of radiotherapy in the last three years were included in the study (n: 12). Previous treatment regimens, baseline PRL and IGF-I levels (ULNR), sella MRI, and immunohistochemical findings were evaluated. Cabergoline was used as an add on (n: 11) or single medical treatment (n: 1). The median duration of treatment with SRL alone was 12 months (range 6–48 months). The mean IGF-I value before cabergoline therapy was 1.45±0.4 ULNR. The mean cabergoline dose and duration of treatment were 1.55±0.75 mg/week and 9±6.3 months, respectively. IGF-I normalization was only achieved in patients with serum IGF-I concentration<1.5×ULNR before the onset of cabergoline treatment (n: 9). In some of the patients with IGF-I normalization, baseline prolactin levels were normal (n: 3). Immunopositivity for prolactin in adenoma tissue was found in three patients with IGF-I normalization. Cabergoline therapy is effective in the normalization of IGF-I levels even in normoprolactinemic acromegaly patients when IGF-I levels are mildly or moderately elevated during SRL therapy.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Effect of Cabergoline Treatment on Disease Control in Acromegaly Patients ; volume:54 ; number:10 ; year:2022 ; pages:664-670 ; Hormone and metabolic research ; 54, Heft 10 (2022), 664-670

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: Hacisahinogullari, Hulya ; Yalin, Gulsah Yenidunya ; Selcukbiricik, Ozlem Soyluk ; Gul, Nurdan ; Bilgic, Bilge ; Uzum, Ayse Kubat ; Tanakol, Refik ; Aral, Ferihan

Weitere Informationen

• DOI: 10.1055/a-1930-6585
• URN: urn:nbn:de:101:1-2411071648088.695133315679
• Rechteinformation: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:27 MESZ