An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
Abstract: The size of lipid droplets varies greatly in vivo and is determined by both intrinsic and extrinsic factors. From an RNAi screen in Drosophila, we found that knocking down subunits of COP9 signalosome (CSN) results in enlarged lipid droplets under high‐fat, but not normal, conditions. We identified CG2064, a retinol dehydrogenase (RDH) homolog, as the proteasomal degradation target of CSN in regulating lipid droplet size. RDH/CG2064 interacts with the lipid droplet‐resident protein Plin2 and the RDH/CG2064‐Plin2 axis acts to reduce the overall level and lipid droplet localization of Bmm/ATGL lipase. This axis is important for larval survival under prolonged starvation. Thus, we discovered an RDH‐Plin2 axis modulates lipid droplet size.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase ; day:08 ; month:02 ; year:2022 ; extent:26
EMBO reports / European Molecular Biology Organization ; (08.02.2022) (gesamt 26)
- Urheber
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Zhao, Xuefan
Wang, Wei
Yao, Yan
Li, Xia
Huang, Xiahe
Wang, Yingchun
Ding, Mei
Huang, Xun
- DOI
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10.15252/embr.202152669
- URN
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urn:nbn:de:101:1-2022020814283442427019
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:33 MESZ
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Beteiligte
- Zhao, Xuefan
- Wang, Wei
- Yao, Yan
- Li, Xia
- Huang, Xiahe
- Wang, Yingchun
- Ding, Mei
- Huang, Xun
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