Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant
Abstract: Many pathogens blunt immune responses because they lack immunogenic structural features, which typically results in disease. Here, we show evidence suggesting that pathogen immunogenicity can be chemically enhanced. Using supramolecular host‐guest chemistry, we complexed onto the surface of a poorly immunogenic bacterium (Staphylococcus aureus) a TLR7 agonist‐based adjuvant. “Adjuvanted” bacteria were readily recognized by macrophages and induced a more pro‐inflammatory immunophenotype. Future applications of this concept could yield treatment modalities that bolster the immune system's response to pathogenic microbes.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant ; day:04 ; month:11 ; year:2022 ; extent:1
ChemBioChem ; (04.11.2022) (gesamt 1)
- Urheber
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Duszenko, Nikolas
van Willigen, Danny M.
Bunschoten, Anton
Velders, Aldrik H.
Roestenberg, Meta
van Leeuwen, Fijs W. B.
- DOI
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10.1002/cbic.202200434
- URN
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urn:nbn:de:101:1-2022110514035834472054
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:34 MESZ
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Beteiligte
- Duszenko, Nikolas
- van Willigen, Danny M.
- Bunschoten, Anton
- Velders, Aldrik H.
- Roestenberg, Meta
- van Leeuwen, Fijs W. B.
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