Mesenchymal Migration on Adhesive–Nonadhesive Alternate Surfaces in Macrophages
Abstract: Mesenchymal migration usually happens on adhesive substrates, while cells adopt amoeboid migration on low/nonadhesive surfaces. Protein‐repelling reagents, e.g., poly (ethylene) glycol (PEG), are routinely employed to resist cell adhering and migrating. Contrary to these perceptions, this work discovers a unique locomotion of macrophages on adhesive–nonadhesive alternate substrates in vitro that they can overcome nonadhesive PEG gaps to reach adhesive regions in the mesenchymal mode. Adhering to extracellular matrix regions is a prerequisite for macrophages to perform further locomotion on the PEG regions. Podosomes are found highly enriched on the PEG region in macrophages and support their migration across the nonadhesive regions. Increasing podosome density through myosin IIA inhibition facilitates cell motility on adhesive–nonadhesive alternate substrates. Moreover, a developed cellular Potts model reproduces this mesenchymal migration. These findings together uncover a new migratory behavior on adhesive–nonadhesive alternate substrates in macrophages.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Mesenchymal Migration on Adhesive–Nonadhesive Alternate Surfaces in Macrophages ; day:21 ; month:05 ; year:2023 ; extent:12
Advanced science ; (21.05.2023) (gesamt 12)
- Urheber
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Xing, Fulin
Dong, Hao
Yang, Jianyu
Fan, Chunhui
Hou, Mengdi
Zhang, Ping
Hu, Fen
Zhou, Jun
Chen, Liangyi
Pan, Leiting
Xu, Jingjun
- DOI
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10.1002/advs.202301337
- URN
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urn:nbn:de:101:1-2023052215073296887038
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:53 MESZ
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Beteiligte
- Xing, Fulin
- Dong, Hao
- Yang, Jianyu
- Fan, Chunhui
- Hou, Mengdi
- Zhang, Ping
- Hu, Fen
- Zhou, Jun
- Chen, Liangyi
- Pan, Leiting
- Xu, Jingjun
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Mesenchymal Migration on Adhesive–Nonadhesive Alternate Surfaces in Macrophages (Adv. Sci. 23/2023)
The Timing of Out-of-Court Settlements Revisited: Theory and Cross- Sectional Evidence from Texas since 1988
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