Chemoselective Alpha‐Deuteration of Amides via Retro‐ene Reaction
Abstract: A synthetically convenient approach for the direct α‐deuteration of amides is reported. This mechanistically unusual process relies on a retro‐ene‐type process, triggered by the addition of deuterated dimethyl sulfoxide to a keteniminium intermediate, generated through electrophilic amide activation. The transformation displays broad functional‐group tolerance and high deuterium incorporation.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Chemoselective Alpha‐Deuteration of Amides via Retro‐ene Reaction ; volume:26 ; number:67 ; year:2020 ; pages:15509-15512 ; extent:4
Chemistry - a European journal ; 26, Heft 67 (2020), 15509-15512 (gesamt 4)
- Creator
- DOI
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10.1002/chem.202004103
- URN
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urn:nbn:de:101:1-2022060416315735561082
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Porte, Vincent
- Di Mauro, Giovanni
- Schupp, Manuel
- Kaiser, Daniel
- Maulide, Nuno
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