Max Schottelius: Pioneer in Pheochromocytoma

Abstract: First descriptions of diseases attract tremendous interest because they reveal scientific insight even in retrospect. Max Schottelius, the pathologist contributing the first histological description of pheochromocytoma, remains anonymous. We reviewed the description by Schottelius and weighed the report in modern context. Schottelius described the classical diagnostic elements of pheochromocytoma, including the brown appearance after exposure to chromate-containing Mueller’s fixative. This color change, known as chromaffin reaction, results from oxidation of catecholamines and is reflected in the name pheochromocytoma, meaning dusky-colored chromate-positive tumor. Thus Schottelius performed the first known histochemical contribution to diagnosis, which is today standard with immunohistochemistry for chromogranin

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Journal of the endocrine society. - 1, 7 (2017) , 957-964, ISSN: 2472-1972

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2019
• Creator: Bausch, Birke ; Tischler, Arthur S. ; Schmid, Kurt Werner ; Leijon, Helena ; Eng, Charis ; Neumann, Hartmut P. H.
• Contributor: Klinik für Innere Medizin IV. Freiburg im Breisgau

Further information

• DOI: 10.1210/js.2017-00208
• URN: urn:nbn:de:bsz:25-freidok-1429288
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:41 PM CET