Boosting Glioblastoma Therapy with Targeted Pyroptosis Induction
Abstract: Glioblastoma (GBM) is a highly aggressive cancer that currently lacks effective treatments. Pyroptosis has emerged as a promising therapeutic approach for cancer, but there is still a need for new pyroptosis boosters to target cancer cells. In this study, it is reported that Aloe‐emodin (AE), a natural compound derived from plants, can inhibit GBM cells by inducing pyroptosis, making it a potential booster for pyroptosis‐mediated GBM therapy. However, administering AE is challenging due to the blood‐brain barrier (BBB) and its non‐selectivity. To overcome this obstacle, AE@ZIF‐8 NPs are developed, a biomineralized nanocarrier that releases AE in response to the tumor's acidic microenvironment (TAM). Further modification of the nanocarrier with transferrin (Tf) and polyethylene glycol‐poly (lactic‐co‐glycolic acid) (PEG‐PLGA) improves its penetration through the BBB and tumor targeting, respectively. The results show that AE‐NPs (Tf‐PEG‐PLGA modified AE@ZIF‐8 NPs) significantly increase the intracranial distribution and tumor tissue accumulation, enhancing GBM pyroptosis. Additionally, AE‐NPs activate antitumor immunity and reduce AE‐related toxicity. Overall, this study provides a new approach for GBM therapy and offers a nanocarrier that is capable of penetrating the BBB, targeting tumors, and attenuating toxicity.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Boosting Glioblastoma Therapy with Targeted Pyroptosis Induction ; day:17 ; month:04 ; year:2023 ; extent:17
Small ; (17.04.2023) (gesamt 17)
- Urheber
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Fang, Xinggang
Chen, Zhuo
Zhou, Wenhui
Li, Tongfei
Wang, Man
Gao, Yujiu
Ma, Shinan
Feng, Ying
Du, Shiming
Lan, Peimin
Chen, Hanyu
Wei, Jiarui
Zhang, Sisi
Li, Zixiang
Liu, Xinglin
Zhang, Hongbo
Guo, Xingrong
Luo, Jie
- DOI
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10.1002/smll.202207604
- URN
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urn:nbn:de:101:1-2023041715081335288736
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:57 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Fang, Xinggang
- Chen, Zhuo
- Zhou, Wenhui
- Li, Tongfei
- Wang, Man
- Gao, Yujiu
- Ma, Shinan
- Feng, Ying
- Du, Shiming
- Lan, Peimin
- Chen, Hanyu
- Wei, Jiarui
- Zhang, Sisi
- Li, Zixiang
- Liu, Xinglin
- Zhang, Hongbo
- Guo, Xingrong
- Luo, Jie
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