Aminopotassiation by Mixed Potassium/Lithium Amides: A Synthetic Path to Difficult to Access Phenethylamine Derivates
Abstract: Insights gained from a comparison of aminometalation reactions with lithium amides, potassium amides and mixed lithium/potassium amides are presented. A combination of structural characterization, DFT calculations and electrophile reactions of aminometalated intermediates has shown the advantages of using a mixed metal strategy. While potassium amides fail to add, the lithium amides are uncontrollable and eliminated, yet the mixed K/Li amides deliver the best of both systems. Aminopotassiation proceeds to form the alkylpotassium species which has enhanced stability over its lithium counterpart allowing for its isolation and thereby its further characterization.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Aminopotassiation by Mixed Potassium/Lithium Amides: A Synthetic Path to Difficult to Access Phenethylamine Derivates ; volume:59 ; number:50 ; year:2020 ; pages:22500-22504 ; extent:5
Angewandte Chemie / International edition. International edition ; 59, Heft 50 (2020), 22500-22504 (gesamt 5)
- Creator
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Seymen, Andreas
Opper, Ulrike
Voß, Andreas
Brieger, Lukas
Otte, Felix
Unkelbach, Christian
O'Shea, Donal F.
Strohmann, Carsten
- DOI
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10.1002/anie.202009318
- URN
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urn:nbn:de:101:1-2022061412302186557670
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
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Associated
- Seymen, Andreas
- Opper, Ulrike
- Voß, Andreas
- Brieger, Lukas
- Otte, Felix
- Unkelbach, Christian
- O'Shea, Donal F.
- Strohmann, Carsten
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