Multifunctional Biomimetic Nanocarriers for Dual‐Targeted Immuno‐Gene Therapy Against Hepatocellular Carcinoma
Abstract: Growing evidences have proved that tumors evade recognition and attack by the immune system through immune escape mechanisms, and PDL1/Pbrm1 genes have a strong correlation with poor response or resistance to immune checkpoint blockade (ICB) therapy. Herein, a multifunctional biomimetic nanocarrier (siRNA‐CaP@PD1‐NVs) is developed, which can not only enhance the cytotoxic activity of immune cells by blocking PD1/PDL1 axis, but also reduce tumor immune escape via Pbrm1/PDL1 gene silencing, leading to a significant improvement in tumor immunosuppressive microenvironment. Consequently, the nanocarrier promotes DC cell maturation, enhances the infiltration and activity of CD8+ T cells, and forms long‐term immune memory, which can effectively inhibit tumor growth or even eliminate tumors, and prevent tumor recurrence and metastasis. Overall, this study presents a powerful strategy for co‐delivery of siRNA drugs, immune adjuvant, and immune checkpoint inhibitors, and holds great promise for improving the effectiveness and safety of current immunotherapy regimens.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Multifunctional Biomimetic Nanocarriers for Dual‐Targeted Immuno‐Gene Therapy Against Hepatocellular Carcinoma ; day:08 ; month:07 ; year:2024 ; extent:16
Advanced science ; (08.07.2024) (gesamt 16)
- Creator
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Sun, Yupeng
Liu, Yan
Li, Rui
Zhang, Cuilin
Wu, Ming
Zhang, Xiaolong
Zheng, Aixian
Liao, Naishun
Zheng, Youshi
Xu, Haipo
Zeng, Rui
Zeng, Yongyi
Liu, Xiaolong
- DOI
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10.1002/advs.202400951
- URN
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urn:nbn:de:101:1-2407091437062.242363197026
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:45 AM CEST
Data provider
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Associated
- Sun, Yupeng
- Liu, Yan
- Li, Rui
- Zhang, Cuilin
- Wu, Ming
- Zhang, Xiaolong
- Zheng, Aixian
- Liao, Naishun
- Zheng, Youshi
- Xu, Haipo
- Zeng, Rui
- Zeng, Yongyi
- Liu, Xiaolong
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