Protective effects of specneuzhenide on renal injury in rats with diabetic nephropathy
Background: We aim to investigate the protective effects and potential mechanisms in specneuzhenide (SPE) on renal injury in rats with diabetic nephropathy (DN). Results: SPE could inhibit the decrease of body weight compared with the model group (P<0.05), and trigger improvement in the renal index (P<0.05). High dose and low dose SPE could trigger a significant decrease in serum IL1β, IL-6 and TNF-α compared with the model group (P<0.05). SPE could attenuate the glomerular lesions in DN rats. SPE induced up-regulation of podocin and CD2AP (P<0.05). Conclusion: SPE showed protective effects on renal injury through attenuating the pathological injury and urine protein. This process may be closely related to the modulation of CD2AP and podocin expression.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Protective effects of specneuzhenide on renal injury in rats with diabetic nephropathy ; volume:14 ; number:1 ; year:2019 ; pages:740-747 ; extent:8
Open medicine ; 14, Heft 1 (2019), 740-747 (gesamt 8)
- Creator
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Yin, Jiangning
Jiang, Jun
Wang, Huajun
Lu, Guoyuan
- DOI
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10.1515/med-2019-0085
- URN
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urn:nbn:de:101:1-2022101114191619981353
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
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Associated
- Yin, Jiangning
- Jiang, Jun
- Wang, Huajun
- Lu, Guoyuan
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