Palladium‐Catalyzed Carbonylation of Allylic Chlorides to β,γ‐Unsaturated Esters/Amides under Mild Conditions

Abstract: Improved procedures for carbonylative transformations (alkoxy‐ and aminocarbonylation) of cinnamyl chloride to synthesize β,γ‐unsaturated esters/amides have been developed. Studying critical reaction parameters (palladium precursors, solvents and bases) enabled the practical preparation of diverse β,γ‐unsaturated esters/amides under mild conditions (low Pd catalyst loading, phosphine‐free, 2 bar CO, 60 °C). The optimal catalytic system shows excellent chemo‐ and regioselectivity for the activation of the allylic C−Cl bonds.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Palladium‐Catalyzed Carbonylation of Allylic Chlorides to β,γ‐Unsaturated Esters/Amides under Mild Conditions ; volume:2022 ; number:30 ; year:2022 ; extent:5 ; European journal of organic chemistry ; 2022, Heft 30 (2022) (gesamt 5)

Contributors, Places and Time

• Creator: Wang, Peng ; Cao, Zhusong .. ; Wang, Yaxin X. ; Neumann, Helfried ; Beller, Matthias

Further information

• DOI: 10.1002/ejoc.202200663
• URN: urn:nbn:de:101:1-2022080915072820751091
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:25 AM CEST