Molecular Networking‐Guided Discovery of Kyonggic Acids in Massilia spp.
Abstract: In recent years, bacteria of the genus Massilia have been identified as promising sources of bioactive natural products. In this study, we used mass spectrometry (MS)‐based molecular networking for the first comprehensive analysis of the secondary metabolome of these microorganisms. Annotation of the detected metabolite clusters with a mass fragmentation database revealed several compounds not previously known to be produced by Massilia species. To secure sufficient material for further structural analyses as well as biological testing, we selected the most promising producer strains from our molecular networking analysis and subjected them to larger‐scale cultivation. Following extraction and UV‐directed isolation, we obtained five metabolites in milligram quantities. In addition to a cyclic dipeptide, we elucidated the structures of four acyl amino acids that are related to thalassotalic acid C from the marine bacterium Thalassotalea sp. The Massilia‐derived kyonggic acids were found to inhibit the enzyme tyrosinase, which is involved in melanin biosynthesis influencing skin and hair pigmentation. This study illustrates the value of combining spectroscopic and computational tools in natural product discovery in order to detect and guide the isolation of previously overlooked bioactive compounds.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Molecular Networking‐Guided Discovery of Kyonggic Acids in Massilia spp. ; day:12 ; month:04 ; year:2024 ; extent:8
European journal of organic chemistry ; (12.04.2024) (gesamt 8)
- Urheber
- DOI
-
10.1002/ejoc.202400017
- URN
-
urn:nbn:de:101:1-2024041314291159425388
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:46 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Steinmetz, Till
- Lindig, Anton
- Lütz, Stephan
- Nett, Markus
Ähnliche Objekte (12)
Structure-guided Discovery of Dual-recognition Chemibodies
Artificial intelligence-guided discovery of gastric cancer continuum
Artificial Intelligence Guided Thermoelectric Materials Design and Discovery
Machine-learning guided discovery of a new thermoelectric material
Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides
Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides
Activity-guided discovery of antioxidants in processed garlic extracts
Machine Learning Guided Discovery of Non‐Linear Optical Materials
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
Advanced lectures on networking : networking 2002 tutorials
Social Networking
Nonspecific networking
Structure-guided Discovery of Dual-recognition Chemibodies
Artificial intelligence-guided discovery of gastric cancer continuum
Artificial Intelligence Guided Thermoelectric Materials Design and Discovery
Machine-learning guided discovery of a new thermoelectric material
Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides
Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides
Activity-guided discovery of antioxidants in processed garlic extracts
Machine Learning Guided Discovery of Non‐Linear Optical Materials
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
Advanced lectures on networking : networking 2002 tutorials
Social Networking
Nonspecific networking
Structure-guided Discovery of Dual-recognition Chemibodies
Artificial intelligence-guided discovery of gastric cancer continuum
Artificial Intelligence Guided Thermoelectric Materials Design and Discovery
Machine-learning guided discovery of a new thermoelectric material
Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides
Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides
Activity-guided discovery of antioxidants in processed garlic extracts
Machine Learning Guided Discovery of Non‐Linear Optical Materials
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
Advanced lectures on networking : networking 2002 tutorials
Social Networking