Targeting the post-irradiation tumor microenvironment in glioblastoma via inhibition of CXCL12

zu Verbundenen Objekten

Abstract: Radiotherapy is a mainstay in glioblastoma therapy as it not only directly targets tumor cells but also depletes the tumor microvasculature. The resulting intra-tumoral hypoxia initiates a chain of events that ultimately leads to re-vascularization, immunosuppression and, ultimately, tumor-regrowth. The key component of this cascade is overexpression of the CXC-motive chemokine ligand 12 (CXCL12), formerly known as stromal-cell derived factor 1 (SDF-1). We here review the role of CXCL12 in recruitment of pro-vasculogenic and immunosuppressive cells and give an overview on future and current drugs that target this axis

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
issn: 2072-6694

Schlagwort
Glioblastom
Strahlentherapie
Chemokin CXCL12

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2019
Urheber

DOI
10.3390/cancers11030272
URN
urn:nbn:de:bsz:25-freidok-1492958
Rechteinformation
Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
25.03.2025, 13:49 MEZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Original beim Datenpartner anzeigen

Beteiligte

Entstanden

  • 2019

Ähnliche Objekte (12)

Distinct glioblastoma subgroups expression altered by metabolic microenvironment

Distinct glioblastoma subgroups expression altered by metabolic microenvironment

Subtype-specific differences in the cellular glioblastoma microenvironment

Subtype-specific differences in the cellular glioblastoma microenvironment

Transcriptome analysis reveals tumor microenvironment changes in glioblastoma

Transcriptome analysis reveals tumor microenvironment changes in glioblastoma

SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment

SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment

Molecular targeting of autophagy in glioblastoma

Molecular targeting of autophagy in glioblastoma

Targeting the glioma associated microenvironment in experimental glioma

Targeting the glioma associated microenvironment in experimental glioma

Small molecule XIAP inhibitors enhance γ-irradiation-induced-apoptosis [Gamma-irradiation-induced-apoptosis] in glioblastoma

Hochschulschrift

Small molecule XIAP inhibitors enhance γ-irradiation-induced-apoptosis [Gamma-irradiation-induced-apoptosis] in glioblastoma

Therapeutic targeting of microRNAs in the tumor microenvironment

Therapeutic targeting of microRNAs in the tumor microenvironment

Targeting the microenvironment in the treatment of arteriovenous malformations

Targeting the microenvironment in the treatment of arteriovenous malformations

PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells

PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells

Novel immunological mechanisms of targeting tumors and their micro-environment

Novel immunological mechanisms of targeting tumors and their micro-environment

Characterizing and targeting the tumor microenvironment in chronic lymphocytic leukemia

Hochschulschrift

Characterizing and targeting the tumor microenvironment in chronic lymphocytic leukemia

Verbundene Objekte