Membrane Proteins Have Distinct Fast Internal Motion and Residual Conformational Entropy
Abstract: The internal motions of integral membrane proteins have largely eluded comprehensive experimental characterization. Here the fast side‐chain dynamics of the α‐helical sensory rhodopsin II and the β‐barrel outer membrane protein W have been investigated in lipid bilayers and detergent micelles by solution NMR relaxation techniques. Despite their differing topologies, both proteins have a similar distribution of methyl‐bearing side‐chain motion that is largely independent of membrane mimetic. The methyl‐bearing side chains of both proteins are, on average, more dynamic in the ps–ns timescale than any soluble protein characterized to date. Accordingly, both proteins retain an extraordinary residual conformational entropy in the folded state, which provides a counterbalance to the absence of the hydrophobic effect. Furthermore, the high conformational entropy could greatly influence the thermodynamics underlying membrane‐protein functions, including ligand binding, allostery, and signaling.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Membrane Proteins Have Distinct Fast Internal Motion and Residual Conformational Entropy ; volume:132 ; number:27 ; year:2020 ; pages:11201-11207 ; extent:7
Angewandte Chemie ; 132, Heft 27 (2020), 11201-11207 (gesamt 7)
- Creator
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O'Brien, Evan S.
Fuglestad, Brian
Lessen, Henry J.
Stetz, Matthew A.
Lin, Danny W.
Marques, Bryan S.
Gupta, Kushol
Fleming, Karen G.
Wand, A. Joshua
- DOI
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10.1002/ange.202003527
- URN
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urn:nbn:de:101:1-2022052911314389304679
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- O'Brien, Evan S.
- Fuglestad, Brian
- Lessen, Henry J.
- Stetz, Matthew A.
- Lin, Danny W.
- Marques, Bryan S.
- Gupta, Kushol
- Fleming, Karen G.
- Wand, A. Joshua
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