Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
Abstract: The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)‐nanocarrier system that binds efficiently to siglec‐10, a member of the CD33 family of siglecs (sialic acid (SA)‐binding immunoglobulin‐like lectins). In particular, a zinc phthalocyanine derivative bearing three SA moieties (PcSA) has been incorporated in the membrane of small unilamellar vesicles (SUVs), retaining its photophysical properties upon insertion into the SUV's membrane. The interaction of these biohybrid systems with human siglec‐10‐displaying supported lipid bilayers (SLBs) has shown the occurrence of weakly multivalent, superselective interactions between vesicle and SLB. The SLB therefore acts as an excellent cell membrane mimic, while the binding with PS‐loaded SUVs shows the potential for targeting siglec‐expressing cells with photosensitizing nanocarriers.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers ; day:21 ; month:06 ; year:2022 ; extent:1
Angewandte Chemie ; (21.06.2022) (gesamt 1)
- Creator
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Almeida‐Marrero, Verónica
Bethlehem, Fleur
Longo, Sara
Bertolino, M. Candelaria
Torres, Tomás
Huskens, Jurriaan
de la Escosura, Andrés
- DOI
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10.1002/ange.202206900
- URN
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urn:nbn:de:101:1-2022062215050049702808
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Almeida‐Marrero, Verónica
- Bethlehem, Fleur
- Longo, Sara
- Bertolino, M. Candelaria
- Torres, Tomás
- Huskens, Jurriaan
- de la Escosura, Andrés
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Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration
Effects of linker and liposome anchoring on lactose-functionalized glycomacromolecules as multivalent ligands for binding galectin-3
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Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration
Effects of linker and liposome anchoring on lactose-functionalized glycomacromolecules as multivalent ligands for binding galectin-3
Targeting triple negative breast cancer stem cells using nanocarriers
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