From nature versus nurture, via nature and nurture, to gene x environment interaction in mental disorders
Abstract: It is now generally accepted that complex mental disorders are the results of interplay between genetic and environmental factors. This holds out the prospect that by studying G x E interplay we can explain individual variation in vulnerability and resilience to environmental hazards in the development of mental disorders. Furthermore studying G x E findings may give insights in neurobiological mechanisms of psychiatric disorder and so improve individualized treatment and potentially prevention. In this paper, we provide an overview of the state of field with regard to G x E in mental disorders. Strategies for G x E research are introduced. G x E findings from selected mental disorders with onset in childhood or adolescence are reviewed [such as depressive disorders, attention-deficit/ hyperactivity disorder (ADHD), obesity, schizophrenia and substance use disorders]. Early seminal studies provided evidence for G x E in the pathogenesis of depression implicating 5-HTTLPR, and condu
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Postprint
begutachtet (peer reviewed)
In: European Child & Adolescent Psychiatry ; 19 (2009) 3 ; 199-210
- Event
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Veröffentlichung
- (where)
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Mannheim
- (when)
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2009
- Creator
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Wermter, Anne-Kathrin
Laucht, Manfred
Schimmelmann, Benno G.
Banaschweski, Tobias
Sonuga-Barke, Edmund J. S.
Rietschel, Marcella
Becker, Katja
- DOI
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10.1007/s00787-009-0082-z
- URN
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urn:nbn:de:0168-ssoar-211084
- Rights
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Open Access unbekannt; Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:37 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wermter, Anne-Kathrin
- Laucht, Manfred
- Schimmelmann, Benno G.
- Banaschweski, Tobias
- Sonuga-Barke, Edmund J. S.
- Rietschel, Marcella
- Becker, Katja
Time of origin
- 2009
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