Recombinant ferritin protects mice against challenge with Echinococcus granulosus?

Abstract: Ferritin is well known as the main intracellular iron storage protein in both prokaryotes and eukaryotes, keeping it in a soluble and non-toxic form, though the role of ferritin as a vaccine candidate in echinococcosis has not yet been delineated. Through our study, ferritin was cloned from Echinococcus granulosus and expressed in Escherichia coli. The recombinant E. granulosus ferritin (rEgferritin) has a molecular weight of 19 kDa and could be recognized by anti-mice serum in Western blotting. The specific antibody was detected by enzyme-linked immunosorbent assay. Mice vaccinated with rEgferritin and challenged intraperitoneally with E. granulosus protoscoleces revealed significant protective efficacy up to 85.6%, compared with the control group. Thus, rEgferritin could be a promising candidate as an effective vaccine to prevent the infection of echinococcosis.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Recombinant ferritin protects mice against challenge with Echinococcus granulosus? ; volume:54 ; number:4 ; year:2009 ; pages:335-340 ; extent:6 ; Acta parasitologica ; 54, Heft 4 (2009), 335-340 (gesamt 6)

Contributors, Places and Time

• Creator: Wang, Yana ; Li, Zongji ; Li, Zhaoyu ; Bo, Yang ; Zhao, Wei

Further information

• DOI: 10.2478/s11686-009-0050-2
• URN: urn:nbn:de:101:1-2405081608342.207438069115
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:00 AM CEST