Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study
Background: Approximately 30% of patients do not respond to implantation of Cardiac Resynchronization Therapy – Defibrillators (CRT-D). The aim of this study was to investigate the potential for cardiac strain speckle tracking to optimize the performance of CRT-D in non-responding patients. Methods: 30 patients not responding to Cardiac Resynchronization Therapy-Defibrillators after 3 months were randomly divided into control and intervention groups. Atrioventricular interval was adjusted so that E and A waves did not overlap, the interventricular interval was subsequently optimized to yield maximum improvement of the sum of longitudinal+radial+circumferential strains. The left ventricular ejection fraction (LVEF) and NYHA improvement 3 months after optimization were evaluated and use of other strain combinations assessed. Results: A significant correlation between the (combined) strain change and LVEF improvement was detected (p<0.01). 75% of patients with non-ischemic etiology of heart failure who did not respond to the original CRT-D reacted favorably with significant LVEF and NYHA improvement. The area strain was the best predictor of LVEF/NYHA improvement in those patients. No significant improvement was recorded in patients with ischemic etiology. Conclusions: AV and VV optimization based on speckle tracking is a very promising method potentially leading to a significant improvement of the outcome of CRT-D, especially in patients with non-ischemic etiology of heart failure.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study ; volume:14 ; number:1 ; year:2019 ; pages:945-952 ; extent:8
Open medicine ; 14, Heft 1 (2019), 945-952 (gesamt 8)
- Creator
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Šipula, David
Kozák, Milan
Šipula, Jaroslav
Homza, Miroslav
Plášek, Jiří
- DOI
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10.1515/med-2019-0111
- URN
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urn:nbn:de:101:1-2022101114112792945746
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:23 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Šipula, David
- Kozák, Milan
- Šipula, Jaroslav
- Homza, Miroslav
- Plášek, Jiří
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Pilot study using 3D–longitudinal strain computation in a multi-parametric approach for best selecting responders to cardiac resynchronization therapy
Patient-specific heart simulation can identify non-responders to cardiac resynchronization therapy
Strain-time curve analysis by speckle tracking echocardiography in cardiac resynchronization therapy: Insight into the pathophysiology of responders vs. non-responders
Cardiac Resynchronization Therapy in Women
Usefulness of NT-pro BNP monitoring to identify echocardiographic responders following cardiac resynchronization therapy
In silico screening method for non-responders to cardiac resynchronization therapy in patients with heart failure: a pilot study
Echo-driven V-V optimization determines clinical improvement in non responders to cardiac resynchronization treatment
Computational Modeling for Cardiac Resynchronization Therapy
Computer assisted optimization of cardiac resynchronization therapy
An unusual failure of cardiac resynchronization therapy
Computer assisted optimization of cardiac resynchronization therapy
Cardiac index in atrio- and interventricular delay optimized cardiac resynchronization therapy and cardiac contractility modulation
Pilot study using 3D–longitudinal strain computation in a multi-parametric approach for best selecting responders to cardiac resynchronization therapy
Patient-specific heart simulation can identify non-responders to cardiac resynchronization therapy
Strain-time curve analysis by speckle tracking echocardiography in cardiac resynchronization therapy: Insight into the pathophysiology of responders vs. non-responders
Cardiac Resynchronization Therapy in Women
Usefulness of NT-pro BNP monitoring to identify echocardiographic responders following cardiac resynchronization therapy
In silico screening method for non-responders to cardiac resynchronization therapy in patients with heart failure: a pilot study
Echo-driven V-V optimization determines clinical improvement in non responders to cardiac resynchronization treatment
Computational Modeling for Cardiac Resynchronization Therapy
Computer assisted optimization of cardiac resynchronization therapy
An unusual failure of cardiac resynchronization therapy
Computer assisted optimization of cardiac resynchronization therapy