Chimeric LuxR Transcription Factors Rewire Natural Product Regulation
Abstract: LuxR‐type transcriptional activator proteins frequently regulate the expression of biosynthetic gene clusters (BGCs). With only a fraction of bacterial BGCs being expressed under standard culturing conditions, modulation of LuxRs would provide a powerful approach to activate silent clusters. We show that by exploiting the modular nature of LuxR proteins, it is possible to construct functional chimeric LuxRs, which enables both the rewiring of quorum sensing systems and the activation of silent BGCs. Importantly, our strategy allowed us to identify the novel natural product pseudomonol from a bacterium of the genus Pseudomonas.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Chimeric LuxR Transcription Factors Rewire Natural Product Regulation ; volume:132 ; number:15 ; year:2020 ; pages:6251-6254 ; extent:4
Angewandte Chemie ; 132, Heft 15 (2020), 6251-6254 (gesamt 4)
- Creator
- DOI
-
10.1002/ange.201914449
- URN
-
urn:nbn:de:101:1-2022052911094937920876
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:34 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Mukherji, Ruchira
- Zhang, Shuaibing
- Chowdhury, Somak
- Stallforth, Pierre
Other Objects (12)
Chimeric LuxR Transcription Factors Rewire Natural Product Regulation
Heterogeneous regulation of bacterial natural product biosynthesis via a novel transcription factor
Bidirectional transcription of a novel chimeric gene mapping to mouse chromosome Yq
Chimeric antigen receptor engineered natural killer cells for cancer therapy
Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
Heterocycles in natural product synthesis
Organic and natural product synthesis
Chemography of Natural Product Space
Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor
Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides
Pseudo Natural Products—Chemical Evolution of Natural Product Structure
Pseudo Natural Products—Chemical Evolution of Natural Product Structure
Chimeric LuxR Transcription Factors Rewire Natural Product Regulation
Heterogeneous regulation of bacterial natural product biosynthesis via a novel transcription factor
Bidirectional transcription of a novel chimeric gene mapping to mouse chromosome Yq
Chimeric antigen receptor engineered natural killer cells for cancer therapy
Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
Heterocycles in natural product synthesis
Organic and natural product synthesis
Chemography of Natural Product Space
Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor
Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides
Pseudo Natural Products—Chemical Evolution of Natural Product Structure
Pseudo Natural Products—Chemical Evolution of Natural Product Structure
Chimeric LuxR Transcription Factors Rewire Natural Product Regulation
Heterogeneous regulation of bacterial natural product biosynthesis via a novel transcription factor
Bidirectional transcription of a novel chimeric gene mapping to mouse chromosome Yq
Chimeric antigen receptor engineered natural killer cells for cancer therapy
Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
Heterocycles in natural product synthesis
Organic and natural product synthesis
Chemography of Natural Product Space
Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor
Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides
Pseudo Natural Products—Chemical Evolution of Natural Product Structure