Selective Sensing of Proteins Using Aptamer Functionalized Nanopore Extended Field‐Effect Transistors
Abstract: The ability to sense proteins and protein‐related interactions at the single‐molecule level is becoming of increasing importance to understand biological processes and diseases better. Single‐molecule sensors, such as nanopores have shown substantial promise for the label‐free detection of proteins; however, challenges remain due to the lack of selectivity and the need for relatively high analyte concentrations. An aptamer‐functionalized nanopore extended field‐effect transistor (nexFET) sensor is reported here, where protein transport can be controlled via the gate voltage that in turn improves single‐molecule sensitivity and analyte capture rates. Importantly, these sensors allow for selective detection, based on the choice of aptamer chemistry, and can provide a valuable addition to the existing methods for the analysis of proteins and biomarkers in biological fluids.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Selective Sensing of Proteins Using Aptamer Functionalized Nanopore Extended Field‐Effect Transistors ; volume:4 ; number:11 ; year:2020 ; extent:8
Small Methods ; 4, Heft 11 (2020) (gesamt 8)
- Creator
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Ren, Ren
Wang, Xiaoyi
Cai, Shenglin
Zhang, Yanjun
Korchev, Yuri
Ivanov, Aleksandar P.
Edel, Joshua B.
- DOI
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10.1002/smtd.202000356
- URN
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urn:nbn:de:101:1-2022060207570167188333
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ren, Ren
- Wang, Xiaoyi
- Cai, Shenglin
- Zhang, Yanjun
- Korchev, Yuri
- Ivanov, Aleksandar P.
- Edel, Joshua B.
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