Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero) Arenes
Abstract: There is a constant need for deuterium‐labelled products for multiple applications in life sciences and beyond. Here, a new class of heterogeneous catalysts is reported for practical deuterium incorporation in anilines, phenols, and heterocyclic substrates. The optimal material can be conveniently synthesised and allows for high deuterium incorporation using deuterium oxide as isotope source. This new catalyst has been fully characterised and successfully applied to the labelling of natural products as well as marketed drugs.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero) Arenes ; day:12 ; month:05 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (12.05.2022) (gesamt 1)
- Creator
- DOI
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10.1002/anie.202202423
- URN
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urn:nbn:de:101:1-2022051315255633710256
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:28 AM CEST
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Associated
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Entwicklung und Anwendung neuer Methoden zur Synthese von Antitumormitteln und antiviraler Wirkstoffe
Iron- and manganese-catalysed (de)hydrogenation reactions
Hydrogen / deuterium exchange reactions : small variations for heavy changes
Late-Stage C–H Deuteration of Organic Compounds via Ligand-Enabled Palladium-Catalyzed Hydrogen Isotope Exchange
Non-noble metal-catalysed carbonylative transformations
Non-noble metal-catalysed carbonylative transformations
Hydrogen generation from the chemical energy carrier methanol : mechanistic insights into the ruthenium-catalysed dehydrogenation reaction and the implementation of a novel base-metal catalyst system
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Transition metal catalyzed carbonylation reactions : carbonylative activation of C-X bonds
Manganese Catalyzed Asymmetric Transfer Hydrogenation of Ketones Using Chiral Oxamide Ligands
Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero) Arenes
Entwicklung und Anwendung neuer Methoden zur Synthese von Antitumormitteln und antiviraler Wirkstoffe
Iron- and manganese-catalysed (de)hydrogenation reactions
Hydrogen / deuterium exchange reactions : small variations for heavy changes
Late-Stage C–H Deuteration of Organic Compounds via Ligand-Enabled Palladium-Catalyzed Hydrogen Isotope Exchange
Non-noble metal-catalysed carbonylative transformations
Non-noble metal-catalysed carbonylative transformations
Hydrogen generation from the chemical energy carrier methanol : mechanistic insights into the ruthenium-catalysed dehydrogenation reaction and the implementation of a novel base-metal catalyst system
Iron catalysis : fundamentals and applications
Organometallics as catalysts in the fine chemical industry
Transition metal catalyzed carbonylation reactions : carbonylative activation of C-X bonds