Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity

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Background: Sevoflurane, a volatile anesthetic, is known to induce widespread neuronal degeneration and apoptosis. Recently, the stress-inducible protein sestrin 2 and adenosine monophosphate-activated protein kinase (AMPK) have been found to regulate the levels of intracellular reactive oxygen species (ROS) and suppress oxidative stress. Notoginsenoside R1 (NGR1), a saponin isolated from Panax notoginseng, has been shown to exert neuroprotective effects. The effects of NGR1 against neurotoxicity induced by sevoflurane were assessed. Methods: Sprague-Dawley rat pups on postnatal day 7 (PD7) were exposed to sevoflurane (3%) anesthesia for 6 h. NGR1 at doses of 12.5, 25, or 50 mg/kg body weight was orally administered to pups from PD2 to PD7. Results: Pretreatment with NGR1 attenuated sevoflurane-induced generation of ROS and reduced apoptotic cell counts. Western blotting revealed decreased cleaved caspase 3 and Bad and Bax pro-apoptotic protein expression. NGR1 substantially upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) expression along with increased heme oxygenase-1 (HO-1) and NAD (P) H quinone oxidoreductase-1 levels, suggesting Nrf2 signaling activation. Enhanced sestrin-2 and phosphorylated AMPK expression were noticed following NGR1 pretreatment. Conclusion: This study revealed the neuroprotective effects of NGR1 through effective suppression of apoptosis and ROS via regulation of apoptotic proteins and activation of Nrf2/HO-1 and sestrin 2/AMPK signaling cascades.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity ; volume:11 ; number:1 ; year:2020 ; pages:215-226 ; extent:12
Translational Neuroscience ; 11, Heft 1 (2020), 215-226 (gesamt 12)

Creator: Zhang, Yibing
Zhao, Yong
Ran, Yongwang
Guo, Jianyou
Cui, Haifeng
Liu, Sha

DOI: 10.1515/tnsci-2020-0118

URN: urn:nbn:de:101:1-2022111513184505561917

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:27 AM CEST

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Zhang, Yibing
Zhao, Yong
Ran, Yongwang
Guo, Jianyou
Cui, Haifeng
Liu, Sha

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Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity

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