Association of Vitamin D With Periodontal Disease: A Narrative Review

Purpose: To present a review of available literature on the association of vitamin D and periodontal disease. Materials and Methods: A thorough search of articles was carried out on the databases PUBMED and MEDLINE regarding vitamin D and periodontal disease. The selected literature included cross-sectional, case-control and prospective and retrospective cohort studies. The main aspects of the association evaluated were a) the association of 25 (OH) D and 1,25 (OH) 2D3 with periodontal disease severity, periodontal disease progression and tooth loss, b) the effect of vitamin D supplementation on periodontal health and c) the association of vitamin D receptor polymorphisms with periodontal disease. A brief overview of the biological mechanisms linking periodontal disease with vitamin D was also included. Results and Conclusions: There is conflicting evidence regarding the effects of 25 (OH) D on periodontal disease severity, progression and tooth loss, with some studies reporting beneficial effects of higher 25 (OH) D serum concentrations on periodontal health and tooth retention, whereas others could not find such an association. Limited evidence also supports a positive association between 1,25 (OH) 2D3 and periodontal health as well as a trend towards better periodontal health with vitamin D supplementation. Finally, various vitamin D polymorphisms were associated with chronic and aggressive periodontitis, with different outcomes reported for the various ethnic populations assessed.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Association of Vitamin D With Periodontal Disease: A Narrative Review ; volume:18 ; number:1 ; year:2020 ; pages:103-114 ; Oral health & preventive dentistry ; 18, Heft 1 (2020), 103-114

Contributors, Places and Time

• Creator: Dragonas, Panagiotis ; el-Sioufi, Iosif ; Bobetsis, Yiorgos A. ; Madianos, Phoebus N.

Further information

• DOI: 10.3290/j.ohpd.a44323
• URN: urn:nbn:de:101:1-2023052208483304094727
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:44 AM CEST