Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release

Abstract: An integrated system combining a magnetically‐driven micromotor and a synthetized protein‐based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of multiple motile sperm cells (ca. 50). The system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs. The binding mechanism between the HA microflake and sperm relies on the interactions between HA and the corresponding sperm HA receptors. Once sperm are captured within the HA microflake, the assembly is trapped and transported by a magnetically‐driven helical microcarrier. The trapping of the sperm‐microflake occurs by a local vortex induced by the microcarrier during rotation‐translation under a rotating magnetic field. After transport, the microflake is enzymatically hydrolyzed by local proteases, allowing sperm to escape and finally reach the target location. This cargo‐delivery system represents a new concept to transport not only multiple motile sperm but also other actively moving biological cargoes.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release ; volume:59 ; number:35 ; year:2020 ; pages:15029-15037 ; extent:9 ; Angewandte Chemie / International edition. International edition ; 59, Heft 35 (2020), 15029-15037 (gesamt 9)

Beteiligte, Orts- und Zeitangaben

• Urheber: Xu, Haifeng ; Medina‐Sánchez, Mariana ; Schmidt, Oliver G.

Weitere Informationen

• DOI: 10.1002/anie.202005657
• URN: urn:nbn:de:101:1-2022061411181767936378
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:30 MESZ