Extracellular fibrin promotes non-small cell lung cancer progression through integrin β1/PTEN/AKT signaling

Abstract: The extracellular matrix (ECM) has been strongly correlated with cancer progression in various tumor types. However, the specific mechanisms underlying ECM-associated tumor behaviors remain unclear. In this study, we found an enriched distribution of fibrin in tumor tissues obtained from high-grade non-small cell lung cancer (NSCLC) patients. For further investigation, we established an in vitro 3D culture system using fibrin gel and found that NSCLC cells grown in this system exhibited increased stemness and tumorigenesis. Mechanistically, we demonstrated that fibrin facilitated the activation of the phosphatase and tensin homolog (PTEN)/protein kinase B (AKT) signaling pathway through integrin β1. Furthermore, we found that blocking integrin β1 signals enhanced the tumor suppressive effects of chemotherapy, providing a novel approach for clinical therapy for NSCLC.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Extracellular fibrin promotes non-small cell lung cancer progression through integrin β1/PTEN/AKT signaling ; volume:18 ; number:1 ; year:2023 ; extent:10 ; Open life sciences ; 18, Heft 1 (2023) (gesamt 10)

Contributors, Places and Time

• Creator: Li, Guilong ; Cai, Jiaying ; Xie, Jianjun ; Dai, Yizhi

Further information

• DOI: 10.1515/biol-2022-0716
• URN: urn:nbn:de:101:1-2023092014132206025484
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:58 AM CEST