Simultaneous Biofilm Disruption, Bacterial Killing, and Inflammation Elimination for Wound Treatment Using Silver Embellished Polydopamine Nanoplatform

Abstract: Due to the presence of spatial barriers, persistent bacteria, and excessive inflammation in bacteria biofilm‐infected wounds, current nanoplatforms cannot effectively address these issues simultaneously during the therapeutic process. Herein, a novel biomimetic photothermal nanoplatform integrating silver and polydopamine nanoparticles (Ag/PDAs) that can damage biofilms, kill bacterial persisters, and reduce inflammation for wound treatment is presented. These findings reveal that Ag/PDAs exhibit a broad‐spectrum antimicrobial activity through direct damage to the bacterial membrane structure. Additionally, Ag/PDAs demonstrate a potent photothermal conversion efficiency. When combined with near‐infrared (NIR) irradiation, Ag/PDAs effectively disrupt the spatial structure of biofilms and synergistically eradicate the resident bacteria. Furthermore, Ag/PDAs show remarkable anti‐inflammatory properties in counteracting bacterium‐induced macrophage polarization. The in vivo results confirm that the topical application of Ag/PDAs significantly suppress Staphylococcus aureus biofilm‐infected wounds in murine models, concurrently facilitating wound healing. This research provides a promising avenue for the eradication of bacterial biofilms and the treatment of biofilm‐infected wounds.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Simultaneous Biofilm Disruption, Bacterial Killing, and Inflammation Elimination for Wound Treatment Using Silver Embellished Polydopamine Nanoplatform ; day:10 ; month:05 ; year:2024 ; extent:10 ; Small ; (10.05.2024) (gesamt 10)

Contributors, Places and Time

• Creator: Ding, Meng ; Zhang, Yu ; Li, Xiaoye ; Li, Qiang ; Xiu, Weijun ; He, Ao ; Dai, Zhuo ; Dong, Heng ; Shan, Jingyang ; Mou, Yongbin

Further information

• DOI: 10.1002/smll.202400927
• URN: urn:nbn:de:101:1-2405101427377.014406376510
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:47 AM CEST