Continuous‐Flow Di‐ N ‐Alkylation of 1 H ‐Benzimidazole in a Fixed‐Bed Reactor

Abstract: A new process for a continuous‐flow di‐N‐alkylation of 1H‐benzimidazole to 1H‐benzimidazole‐3‐ium iodide by methylene iodide in the presence of potassium carbonate in a fixed‐bed reactor is presented. The synthesis was transferred from batch to continuous operation with similar yields and conversion rates. Moreover, the influence of temperature and residence time in the continuous flow setup was characterized; optimized conditions led to a doubling of yield. In addition, the continuous flow allowed for a better control of the two‐step reaction by adding an additional tube reactor after the fixed bed that further enhanced the overall performance. With this, the continuous‐flow system presented itself as superior due to higher available temperatures and a better controllability.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Continuous‐Flow Di‐ N ‐Alkylation of 1 H ‐Benzimidazole in a Fixed‐Bed Reactor ; volume:42 ; number:10 ; year:2019 ; pages:2215-2222 ; extent:8
Chemical engineering & technology ; 42, Heft 10 (2019), 2215-2222 (gesamt 8)

Creator
Sauk, Tobias
Henke, Laurids
Xiao, Chunyu
Hartig, Dave
Scholl, Stephan

DOI
10.1002/ceat.201900114
URN
urn:nbn:de:101:1-2022081408463332504717
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:37 AM CEST

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