Multiple Myeloma: Molecular Pathogenesis and Disease Evolution
Background: Multiple myeloma is the second most common hematologic malignancy, which to date remains incurable despite advances in treatment strategies including the use of novel substances such as proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. Summary: The bone marrow-based disease is preceded by the 2 sequential premalignant conditions: monoclonal gammopathy of undetermined significance and smoldering myeloma. Plasma cell leukemia and extramedullary disease occur, when malignant clones lose their dependency on the bone marrow. Key genetic features of these plasma cell dyscrasias include chromosomal aberrations such as translocations and hyperdiploidy, which occur during error-prone physiologic processes in B-cell development. Next-generation sequencing studies have identified mutations in major oncogenic pathways and tumor suppressors, which contribute to the pathogenesis of multiple myeloma and have revealed insights into the clonal evolution of the disease, particularly along different lines of therapy. More recently, the importance of epigenetic alterations and the role of the bone marrow microenvironment, including immune and osteogenic cells, have become evident. Key Messages: We herein review the current knowledge of the pathogenesis of multiple myeloma, which is crucial for the development of novel targeted therapeutic strategies. These can contribute to the endeavor to make multiple myeloma a curable disease.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Multiple Myeloma: Molecular Pathogenesis and Disease Evolution ; volume:44 ; number:12 ; year:2021 ; pages:672-681 ; extent:10
Oncology research and treatment ; 44, Heft 12 (2021), 672-681 (gesamt 10)
- Urheber
- DOI
-
10.1159/000520312
- URN
-
urn:nbn:de:101:1-2021121523203347653352
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:29 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Heider, Michael
- Nickel, Katharina
- Högner, Marion
- Bassermann, Florian
Ähnliche Objekte (12)
Asymptomatic multiple myeloma molecular background of progression, evolution, and prognosis
Roles of miRNA dysregulation in the pathogenesis of multiple myeloma
Pathogenesis of bone disease in multiple myeloma: from bench to bedside
Targeted protein degradation in the pathogenesis and therapy of multiple myeloma
Multiple myeloma
The role of JunB in multiple myeloma pathogenesis: focus on angiogenesis
Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis
Treatment evolution and improved survival in multiple myeloma in Taiwan
The role of the SCF-Fbxo9 in the pathogenesis and therapy of Multiple Myeloma
Single-cell technologies in multiple myeloma: new insights into disease pathogenesis and translational implications
The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
Imaging of Multiple Myeloma
Asymptomatic multiple myeloma molecular background of progression, evolution, and prognosis
Roles of miRNA dysregulation in the pathogenesis of multiple myeloma
Pathogenesis of bone disease in multiple myeloma: from bench to bedside
Targeted protein degradation in the pathogenesis and therapy of multiple myeloma
Multiple myeloma
The role of JunB in multiple myeloma pathogenesis: focus on angiogenesis
Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis
Treatment evolution and improved survival in multiple myeloma in Taiwan
The role of the SCF-Fbxo9 in the pathogenesis and therapy of Multiple Myeloma
Single-cell technologies in multiple myeloma: new insights into disease pathogenesis and translational implications
The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
Imaging of Multiple Myeloma
Asymptomatic multiple myeloma molecular background of progression, evolution, and prognosis
Roles of miRNA dysregulation in the pathogenesis of multiple myeloma
Pathogenesis of bone disease in multiple myeloma: from bench to bedside
Targeted protein degradation in the pathogenesis and therapy of multiple myeloma
Multiple myeloma
The role of JunB in multiple myeloma pathogenesis: focus on angiogenesis
Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis
Treatment evolution and improved survival in multiple myeloma in Taiwan
The role of the SCF-Fbxo9 in the pathogenesis and therapy of Multiple Myeloma
Single-cell technologies in multiple myeloma: new insights into disease pathogenesis and translational implications
The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma