The LRG-TGF--Alk-1/TGFRII-Smads as Predictive Biomarkers of Chronic Hydrocephalus after Aneurysmal Subarachnoid Hemorrhage

Abstract: BackgroundChronic hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH); however, the risk factors and the mechanisms underlying its occurrence have yet to be fully elucidated. The purpose of this study was to identify biomarkers that could be used to predict chronic hydrocephalus after aSAH and to investigate the relationships. MethodsWe analyzed cerebrospinal fluid (CSF) samples from 19 patients with chronic hydrocephalus after aSAH and 44 controls without hydrocephalus after aSAH. Enzyme-linked immunosorbent assay was used to determine the levels of leucine-rich alpha-2-glycoprotein (LRG), transforming growth factor- (TGF-), Smad1, Smad4, Smad5, Smad8, activin receptor-like kinase 1 (Alk-1), activin receptor-like kinase 5 (Alk-5), P38, and TGF- type II receptor (TGFRII) in CSF samples. ResultsIn the CSF of patients with chronic hydrocephalus after aSAH, the levels of LRG, TGF-, Alk-1, Smad5, and TGFRII were significantly increased (p0.05). The analysis also identified significant correlations between specific biomarkers: LRG and Smad1, LRG and Smad5, TGF- and Alk-1, and Alk-1 and Smad4 (p<0.05); the Pearson's correlation coefficients for these relationships were 0.341, 0.257, 0.256, and 0.424, respectively. ConclusionThe levels of LRG, TGF-, Alk-1, TGFRII, Smad1/5/8, and Smad4 in the CSF are potentially helpful as predictive biomarkers of chronic hydrocephalus after aSAH. Moreover, the LRG-TGF--Alk-1/TGFRII-Smad1/5/8-Smad4 signaling pathway is highly likely to be involved in the pathogenic process of chronic hydrocephalus after aSAH.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: The LRG-TGF--Alk-1/TGFRII-Smads as Predictive Biomarkers of Chronic Hydrocephalus after Aneurysmal Subarachnoid Hemorrhage ; day:21 ; month:08 ; year:2023 ; Journal of neurological surgery / A. Part A, Central European neurosurgery ; (21.08.2023)

Contributors, Places and Time

• Contributor: Ma, Dongying ; Ma, Luyao ; Zhao, Yongqiang ; Li, Yongli ; Ye, Wei ; Li, Xianfeng

Further information

• DOI: 10.1055/s-0043-1771277
• URN: urn:nbn:de:101:1-2023100512340879220839
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:56 AM CEST