Management and Clinical Outcomes of Membranous Nephropathy, IgA Nephropathy, and Minimal Change Disease Two Years Post-Kidney Biopsy

Abstract: Introduction: This study evaluated the phenotypic and pathology characteristics of patients undergoing kidney biopsy at a single center, while also determining the frequency and factors associated with clinical outcomes. Methods: The incidence and distribution of biopsy-proven kidney diseases in 2000–2019 were surveyed. Consecutive individuals diagnosed with membranous nephropathy (MN), immunoglobulin A nephropathy (IgAN), and minimal change disease (MCD) between August 2015 and December 2019 were enrolled in the prospective 2-year follow-up study. Outcomes included remission of proteinuria and kidney disease progression events. Multivariable-adjusted Cox proportional hazards model was applied. Results: 4,550 kidney biopsies were performed in 2000–2019, showing a noticeable increase in the proportion of MN. 426 patients were enrolled in the follow-up cohort. 346 (81.2%) achieved remission of proteinuria, 39 (9.2%) suffered kidney disease progression and 51.3% of them were diagnosed with IgAN. Kidney pathological diagnosis (MN vs. MCD: hazard ratio [HR], 0.42; 95% confidence interval [95% CI], 0.31–0.57; IgAN vs. MCD: 0.58; 0.39–0.85), levels of 24-h urine protein at biopsy (1.04; 1.00–1.08) and presence of nodular mesangial sclerosis (0.70; 0.49–0.99) were significantly correlated with remission of proteinuria after adjusting for baseline variables. 24-h urine protein levels at biopsy (1.14; 1.04–1.25) and the presence of crescents (2.30; 1.06–4.95) were the independent risk factors for kidney disease progression events after adjusting for baseline variables. Conclusion: The increasing frequency of MN has been affirmed over the past 2 decades. The therapeutic status, clinical outcomes, and factors influencing these outcomes were presented in this single-center study for the three primary glomerular diseases.
Glomerular disease remains the major reason of kidney failure in Asia. Numerous reports have presented the characteristics of diverse glomerulopathies across different countries. However, relatively little is known regarding the outcomes of different glomerulopathies among Chinese populations. This study used SPSS software and R to analyze and evaluate the characteristics of patients undergoing kidney biopsy – a method to diagnose kidney diseases, at a single center, while also determining the frequency and factors associated with outcomes. The incidence and distribution of biopsy-proven kidney diseases in 2000–2019 were surveyed. Consecutive individuals diagnosed with three primary glomerulopathies between August 2015 and December 2019 were enrolled in the study. A total of 4,550 kidney biopsies were conducted, with a notable increasing trend observed in the proportion of membranous nephropathy-one of the glomerular diseases. Furthermore, three primary glomerular diseases were presented with their clinicopathologic features, followed-up treatment, the outcomes and factors influencing these outcomes within 2 years after biopsy. The influence of several clinicopathologic features on outcomes was confirmed, including levels of 24-h urine protein at biopsy, kidney pathological diagnosis, and pathological change. The study presents the comprehensive mapping of kidney diseases diagnosed by biopsy. The therapeutic status, clinical outcomes, and factors influencing these outcomes were presented for the three main glomerular diseases. Hereby, data and experience from the single center provide valuable insights into a real-world clinical practice environment.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Management and Clinical Outcomes of Membranous Nephropathy, IgA Nephropathy, and Minimal Change Disease Two Years Post-Kidney Biopsy ; volume:49 ; number:1 ; year:2024 ; pages:345-354 ; extent:10 ; Kidney & blood pressure research ; 49, Heft 1 (2024), 345-354 (gesamt 10)

Beteiligte, Orts- und Zeitangaben

• Urheber: Guo, Xiaojiao ; Tie, Xuan ; Zhang, Yuyu ; Dai, Yemei ; Yao, Shulei ; Qiao, Xi ; Wang, Lihua ; Su, Xiaole

Weitere Informationen

• DOI: 10.1159/000538851
• URN: urn:nbn:de:101:1-2412260139448.300895306527
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:26 MESZ