Large‐Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis
Abstract: Neurosyphilis (NS) is a central nervous system (CNS) infection caused by Treponema pallidum (T. pallidum). NS can occur at any stage of syphilis and manifests as a broad spectrum of clinical symptoms. Often referred to as “the great imitator,” NS can be easily overlooked or misdiagnosed due to the absence of standard diagnostic tests, potentially leading to severe and irreversible organ dysfunction. In this study, proteomic and machine learning model techniques are used to characterize 223 cerebrospinal fluid (CSF) samples to identify diagnostic markers of NS and provide insights into the underlying mechanisms of the associated inflammatory responses. Three biomarkers (SEMA7A, SERPINA3, and ITIH4) are validated as contributors to NS diagnosis through multicenter verification of an additional 115 CSF samples. We anticipate that the identified biomarkers will become effective tools for assisting in diagnosis of NS. Our insights into NS pathogenesis in brain tissue may inform therapeutic strategies and drug discoveries for NS patients.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Large‐Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis ; day:21 ; month:02 ; year:2024 ; extent:12
Advanced science ; (21.02.2024) (gesamt 12)
- Creator
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Li, Jun
Ma, Jie
Liu, MingJuan
Li, Mansheng
Zhang, Ming
Yin, Wenhao
Wu, Mengyin
Li, Xiao
Zhang, Qiyu
Zhang, Hanlin
Zheng, Heyi
Mao, Chenhui
Sun, Jian
Wang, Wenze
Lyu, Wei
Yue, Xueping
Weng, Wenjia
Li, Juan
Chen, Fengxin
Zhu, Yunping
Leng, Ling
- DOI
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10.1002/advs.202307744
- URN
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urn:nbn:de:101:1-2024022214232731086247
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:59 AM CEST
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Associated
- Li, Jun
- Ma, Jie
- Liu, MingJuan
- Li, Mansheng
- Zhang, Ming
- Yin, Wenhao
- Wu, Mengyin
- Li, Xiao
- Zhang, Qiyu
- Zhang, Hanlin
- Zheng, Heyi
- Mao, Chenhui
- Sun, Jian
- Wang, Wenze
- Lyu, Wei
- Yue, Xueping
- Weng, Wenjia
- Li, Juan
- Chen, Fengxin
- Zhu, Yunping
- Leng, Ling
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Mega-events, local economies, and global status: what happened before the 2008 Olympics in Beijing and the 2010 World Expo in Shanghai
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